ID A0A067CY02_SAPPC Unreviewed; 1955 AA.
AC A0A067CY02;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=HEAT repeat-containing protein 1 {ECO:0000256|RuleBase:RU367065};
GN ORFNames=SPRG_00426 {ECO:0000313|EMBL:KDO35584.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO35584.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO35584.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO35584.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000256|RuleBase:RU367065}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU367065}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family.
CC {ECO:0000256|ARBA:ARBA00010559, ECO:0000256|RuleBase:RU367065}.
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DR EMBL; KK583189; KDO35584.1; -; Genomic_DNA.
DR RefSeq; XP_012193915.1; XM_012338525.1.
DR STRING; 695850.A0A067CY02; -.
DR EnsemblProtists; KDO35584; KDO35584; SPRG_00426.
DR GeneID; 24123070; -.
DR KEGG; spar:SPRG_00426; -.
DR VEuPathDB; FungiDB:SPRG_00426; -.
DR OMA; NDVMWKQ; -.
DR OrthoDB; 5480100at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; BAP28; 1.
DR PANTHER; PTHR13457:SF1; HEAT REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367065};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|RuleBase:RU367065};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|RuleBase:RU367065};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552,
KW ECO:0000256|RuleBase:RU367065}.
FT DOMAIN 1656..1822
FT /note="BP28 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01036"
SQ SEQUENCE 1955 AA; 212730 MW; 6D3154537FF644CA CRC64;
MSTSSLASQL HALQVQTTGA SSQRNIASFL HEPKVAAKID GRTTFELAKS AMETLCSMDG
SLDVFQHTLL HPNKAHAQYS RMLLTKEEVV ALDLELGLLL DALSPYFLLP PTHQVIEFLV
RKYEIHVWNV DQILAMTICY HESPVFARLI TICDLAKHPR WAFLEHVKTN NVPLLRANLS
KRCFADYSLV SFLHTAAVRI GARNAKLIAL YALVAMEILE KSRVSENILR WVLPNIIDGL
KDKSFPERQT AAYMVATKLT THATLSPAAR QQLVVVIAKT APAHAQFDAF LCLIGVLQSQ
PFETFPTEAL KHIFKFDDVP QLVMDAMEAY DTTKFLALFL DAVALAHTHA TSEQLFLDLI
NALGQIVAPL VASLVRSMLA AAHSTPSVAD RLQRLLLVLS KRYPEPFDAG LNAMLTDAGL
DSDLQSFCVN FVSTSFTGTA AAMHVPLAES GVSLLLSLDH PTVSVRLHAL SVLAEMDAAA
LEDPDVLLRR LNDDAPSVIV AALVPAVATL LLQTASATQL LDQIAISLNA RAFNSAFATA
MTALVTFVTG PFRDIHGAAY DATLLDMLLV FAPQSTIVAT KPVVAWTTVA PLIATLSVSP
FTNGLSKTTT TDDVLGHFGA QTTLAAAPIV EAWAVPSVHR HTPLPLLAMR VLNDGRQATT
PGLAAPLLTL LTTTWTALNA STPIDSVDRP RIAEVVEVVC DLMRTSFKTD AVTYDASLVL
LLSSTSGYFT LVQPVLHAAL AAEASHWTDL FHSLCRLVHT DAPAHVLTRS VMLLSVMIEC
TPSMVSIGDV HHVVLALLVA LAHAHTALRN AAAQCLKSLT KLSLADKKSR EAFAVYTPTL
TALLKVKEEL SMDASYVATF CSAHVSKDKA FLARVLTTAL VPHDALSSTL LQRVRNVLRV
LHLVHLDAVW TTTIAWFMPL LKTSLTPLTA SIGADLLSHY LRAPASATYD VVLATVAAPS
AAPLHSHVAK TMTSTWFGAL PMGKQTTLVQ ALVVLLRTGA ESTPSDVASL LVRLSLPVRI
VKGLLSVTSE PTWAAQTTCV LEVVSNLIAT YAVDDLNALL SPLHAVLAQF VAAKDDVSEY
SVQMVLTALH GVAVGLRGHA SSTTHATSFV ELTLRVVQHT ISQQTRNAAL LFVSSLVDLC
PTHVLQSLVP ILTFASQLQL DEYSFHVLQE IVTHAVPYVH TDASDISTQQ FLATFVAAFE
TLPIARRSTL FHVLLTALGA HDDDAAAIAV ALLLQHANDV PARSAFCHSL LEALDADLQM
RALVSLLSIA GQLHSHLAPR AKDDDEDEDD DDETEDVAFE IDPKLANATL DRIVSFVPRH
LERKALHHQL LDNSDVEKSL QHAYLLLAQG ILLFLRRVTK TKEALAAKKS SMADRWDAIA
ATALEAMNNL QQLLTAPGFV AVIGELLQHE DGVIRRRALQ LLNERIEETE ATLTFEEELL
FVDMLDDLSS VLEDPSALLT DKQMAILSVD VLTRFFAHKH AQPFLNILPT VMACCKLPLD
VTANGHVIGS AFVCLSNLCQ SLGPAVFPFV PQFFPTLLHC LDVSTSAGTA DASLTLTLQQ
CLLAAMRAMT TKFPQFLVSY LPKMLHLLFV PSLLNVHHVQ IRVSVDATIL ALATGTELRN
LLPALMELYP VCCSRGDVAL LRFFEMVTTI VSGMDRAAVK AHMAGLMRLY LVALDLRRLH
PSIGEHVEDQ LIAALLALVM KLSEKQLKPL FLKLVSWVDV VLPTTQGPSH ARQVVFFRVV
SQLSEKLKSI FVPYFAHILP LCASILLSAI DAGAALLEAE DADGFFERPT KKAKKEVEDP
WPLATHVVTA LIGCCSHDTD GFMDKEKFDV VMPPLVDLLG LASLEVARPV VDGAVQALAH
LAWAAKNDLL WKPMHHRILM KSRAEEPAVR LATLQTIEQC YAIVGEEFLA MLPESIPFLA
ELLEDHDANV EALCHKVIRQ IEDISGESLD QYLTA
//
