ID A0A067EBT9_CITSI Unreviewed; 394 AA.
AC A0A067EBT9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Legumain prodomain domain-containing protein {ECO:0000259|Pfam:PF20985};
GN ORFNames=CISIN_1g016176mg {ECO:0000313|EMBL:KDO48391.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO48391.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO48391.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; KK785143; KDO48391.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067EBT9; -.
DR STRING; 2711.A0A067EBT9; -.
DR MEROPS; C13.001; -.
DR PaxDb; 2711-XP_006477253-1; -.
DR eggNOG; KOG1348; Eukaryota.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005773; C:vacuole; IEA:GOC.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR CDD; cd21115; legumain_C; 1.
DR Gene3D; 1.10.132.130; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR043577; AE.
DR InterPro; IPR048501; Legum_prodom.
DR InterPro; IPR046427; Legumain_prodom_sf.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR12000:SF54; VACUOLAR-PROCESSING ENZYME BETA-ISOZYME; 1.
DR Pfam; PF20985; Legum_prodom; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500139; AE; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 281..377
FT /note="Legumain prodomain"
FT /evidence="ECO:0000259|Pfam:PF20985"
FT ACT_SITE 78
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 120
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ SEQUENCE 394 AA; 44056 MW; 5C7E937023C35A8C CRC64;
MYDDIAMHEL NPRPGVIINH PQGENLYDGV PKDYTGEHVT AQNLYAVLLG DRKAVKGGSG
KVVNSKANDR IFIFYSDHGG PGVLGMPNMP YVYAMEFIDV LKKKHAAKSY KGMVIYVEAC
ESGSIFEGVM PKDLDIYVTT ASNAQESSFG TYCPGMDPSP PPEYITCLGD LYSVAWMEDS
ETHNLKRETI SQQYQAVKER TSNFNNYNSG SHVMEYGNTS VKSEKLYLYQ GFDPASTNFP
PNKLQPDQMG VVNQRDADLL FMWHMYKNAA EGSEKKSEML KQITETMRHR KHLDASIDMI
GVILFGPDKG SRILNSVRAR GLPLVDDWQC LKSMVRVFET HCGSLTQYGM KHMRAFANIC
NSGVSQALME ETSEAACSGN ELRQWHPAIR GYSA
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