ID A0A067F6N3_CITSI Unreviewed; 3776 AA.
AC A0A067F6N3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=CISIN_1g000012mg {ECO:0000313|EMBL:KDO59132.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO59132.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO59132.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UPL family. TOM1/PTR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00034494}.
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DR EMBL; KK784942; KDO59132.1; -; Genomic_DNA.
DR STRING; 2711.A0A067F6N3; -.
DR PaxDb; 2711-XP_006474873-1; -.
DR eggNOG; KOG0939; Eukaryota.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd14327; UBA_atUPL1_2_like; 1.
DR Gene3D; 6.10.250.1630; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF446; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF06012; DUF908; 2.
DR Pfam; PF06025; DUF913; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF14377; UBM; 3.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50330; UIM; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1306..1347
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 3435..3776
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 691..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1527..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1739..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1813..1832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2043..2121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2159..2230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2388..2416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2432..2505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2552..2600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2652..2677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2695..2716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3059..3104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2060..2084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2085..2099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2100..2114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2165..2197
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2212..2230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2432..2455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2484..2505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2552..2566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2652..2675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3085..3100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3743
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 3776 AA; 412924 MW; C33D40CFDB0E96C5 CRC64;
MKLKRRRALE VPPKIRSVIN SITAVPLENI DEPLKNFLWE FDKGDFHHWV DLFNHFDSFF
DKHIKSRKDL QVEDNFLESD PPFPREAVLQ ILRVIRIILE NCTNKHFYSS YEQHLSALLA
STDPDVVEAC LQTLAAFLKK TIGKYTIRDS SLNSKLFALA QGWGGKEEGL GLIECAVQDG
CDPIAYELGC TFHFEFYALN ESSGEFSVEE QSTRGLQIIH LPNINTRPET DLELLNKLVV
EFKVPASLRF SLLSRLRFAR AFGSLAARQQ YTCIRLYAFI VLVQASSDAD DLVSFFNSEP
EFVNELVTLL SYEDAVPEKI RILCLLSLVA LCQDRSRQPT VLTAVTSGGH CGILSSLMQK
TIDSVLSNSS KWSVVFAEAL LSLVTVLVSS SSGCSAMREA GFIPTLLPLL KDTDPQHLHL
VSTAVHILEA FMDYSNPAAA LFRDLGGLDD TIYRLNVEVS YVEAGSKQRK DSDCSRNSSQ
IVAGSSSDLD NMQPLYSEAL VSYHRRLLMK ALLRAISLGT YAPGNTARVY GSEESLLPQC
LCIIFRRAKD FGGGVFSLAA TVMSDLIHKD PTCYPVLDAA GLPSAFLDAI MDGVLCSAEA
IICIPQCLDA LCLNNNGLQA VKDRNALRCF VKIFTSRAYS RVLAGDTPGS LSSGLDELMR
HASSLRSPGV DMVIEILNAI IKVGSGVDAS GLSTDPQSDS APVPMETDAE DRNLVLPDDR
ESSKMESSEQ SAESSSDASL VNIELFLPDC VSNVARLLET ILQNADTCRI FVEKKGIDAV
LQLFTLPLMP LSASVGQSIS AAFKNFSPQH SASLARTVCS FLREHLKLTN ELLLSLGGTQ
LAAVESGKQN KILRHLCSLE GLLSLSNFLL KGTSTVISEL STADADVLKD LGRTYREIVW
QISLCNETKA DEKRNGDQEA ENVEAAPSTV TGRESDHDEN IPAVRYMNPV SIRNGSQSLW
GGERDFLSVV RAGEGLHRRN RHGLSRIRGG RTSRHLEALN IDSEVLPNLP ETSSSQDLKK
KSPDVLVMEM LNKLASTLRA FFTALVKGFT SPNRRRADSG SLSSASKTLG TALAKTFLEA
LSFSEYSSSS SSSSSSCSGL DMSLSVKCRY LGKVVDDMAA LTFDSRRRTC YTAMVNNFYV
HGTFKELLTT FEATSQLLWT LPFSVPASGI DPQNAGEGSK LNHSTWLLDT LQSYCRVLEY
FVNSGLLLSP TSASQAQLLV QPVAVGLSIG LFPVPRDPET FVRMLQSQVL DVILPVWNHP
LFPNCSPGFI ASVISLVTHA YSGVGEVKRN RNGIAGSTSQ RFMPPPPDEN TIATIVDMGF
SRPRAEEALR RVETNSVEMA MEWLLTHAED PVQEDDELAR ALALSLGNSS ETTKADSVDK
AMDVPIEEGQ VKVPPIDDVL ASSVKLFQSG DSLAFPLTDL LVTLCHRNKG EDRPRVVSYF
VQQLKLCSLD FSRDTSPLCM ISHIITLLIS EDGSTREIAA QNGVVPAVVD ILMNFTARNE
IRNEIGAPKC VSALLLILDN MLQSRPGVVS ESTDGAQTEP QPDPSGEHAL STPASADEKK
LDLDIDEKKS GLPFEKVLGT STGYLTMEES HKVLLVACDL IKQHVPAMIM QAVLQLCARL
TKTHALALQF LENGGLVALF SLPRSCFFPG YDTVASAIIR HLLEDPQTLQ TAMEWEIRQT
LSSNRHSGRI LPRTFLTSMA PVISRDPVVF MKAAAAICQL ESSGGRAYVV LAKEKEKDKD
KSKSSGMELG LSSNDSVRIS ENKNQDGLGK CSKGHKKIPA NLTQVIDQLL EIVLKYPLPK
SGEDDLASME VDEPATKVKG KSKIDETRKT ETESERSAGL AKVTFVLKLL SDILLMYVHA
VGVILKRDLE GLLRGSNHPD GSGHGGIIHH VLHRLLPLSI ENSAGPDEWR DKLSEKASWF
LVVLCGRSGE GRKRVINELV KALSSFSNME SNSTKSSLLP DKKVYGFVDL AYSILSKNSS
STNLPGPGCS PDIAKSMIDG GMVQCLTSIL QVIDLDYPDA PKTVNLILKV LESLTRAANA
SEQVFKSDGG NKKKSMGSNG RHDQLTASAA GTMEHNQNRS NQPEVADVED SEQHQGNSRS
EGNHETNANQ SAEQDMGVEV EEATTANPPM ELGEDFMRDE IEEGGVINNT DQIEMTFRVE
NRADDDMGDD DDDMGDDGED DEDDDEGDDD DEDIAEDGAG MMSLADTDVE DHDDTGLGDD
YNDEMNDEED DDFHENRVIE VRWREALDGL DHLQVLGQPG AASGLIDVAA EPFEGVNVDD
LFGLRSRPLG FERRRQAGRS SFERSVTEAS GFQHPLLSRP SQSGDLVSMW SGGNSSRDLE
ALSSGSFDVA HFYMFDAPVL PYDHVSGSLF GDRLGGAAPP PLTDYSVGMD SLHLSGRRGP
GDGRWTDDGQ PQAGAQASAI AQAVEEHFVS QLRSVTPESN LVERQSQNSG EQERQPTDIP
PIIEDQTAAE GENVGRQENE GQDPENGSET ADQQSNPTVG SEPINSDAVE NEHMVIQPLS
LNTSSNGDDI MEIGEGNGTT AEQVEAIPET ISSAPDSHSD LQHRGASEVS ANLHDMSAPV
GSGDESSRMD DHSGNHLLDS GLEMPNTNDV HASSVSVNTD IDMTGADVEG NQTEQPMPAA
ELGVDVTLSR QSTLDSQDAN QTDQTSTNNE GPSASAIDPT FLEALPEDLR AEVLASQQSQ
SVQPPTYTPP SADDIDPEFL AALPPDIQAE VLAQQRAQRL AHQGEGQPVD MDNASIIATF
PADLREEVLL TSSEAVLSAL PSPLLAEAQM LRDRAMSHYQ ARSLFGGSHR LNGRRTGLGF
DRQMVMDRGV GVTIGRRAAS AITDSLKVKE IEGEPLLDAN ALKALIRLLR LAQPLGKGLL
QRLLLNLCAH SVTRATLVRL LLDMIKPEAE GSVTGLAAIN SQRLYGCQSN VVYGRSQLLD
GLPPLVFRQI LEIMAYLATN HSAVANMLFY FDTSIVLESS SPKYSETKAK GKEKIMDGAA
STEPLGNLEG GDVPLVLFLK LLNRPLFLRS TAHLEQVMGL LHVIVYTAAS KLECQSQSEP
AVENSQKPMI DEASGDVCKD PSSTEPESSQ EDKHACIKTS SSDGKRSIDT YDILSKLPQS
DLRNLCSLLG HEGLSDKVYM LAGEVLKKLA SVAALHRKFF ASELSQLAHS LSISAVNELV
TLRDTHMLGL SAGSMAGAAI LRVLQALSSL TSASIGESGG QGCDGEQEEQ ATMWNLNLAL
EPLWQELSDC ITMTETQLGQ SSFCPSVSNM NVGEPLPGTS STSPLPPGTQ RLLPFIEAFF
VLCEKLQANH IMIQQDHADV TATEVKESAG CSYSSTPKCS DDSQRKLDGA VTFARFSEKH
RRLLNAFIRQ NPSLLEKSLS MMLKAPRLID FDNKRAYFRS KIRQQHEQHL SGPLRISVRR
AYVLEDSYNQ LRMRSTQDLK GRLNVHFQGE EGIDAGGLTR EWYQLLSRVI FDKGALLFTT
VGNNASFQPN PNSVYQTEHL SYFKFVGRVV AKALFDGQLL DVHFTRSFYK HMLGVKVTYH
DIEAVDPDYY KNLKWMLEND VSDIPDLTFS MDADEEKHIL YEKTEVTDYE LKPGGRNIRV
TEETKHEYVD LVADHILTNA IRPQITSFLE GFGELVPREL ISIFNDKELE LLISGLPEID
LDDLRANTEY TGYTAASTVV QWFWEVAKAF NKEDMARLLQ FVTGTSKVPL EGFKALQGIS
GPQKFQIHKA YGAPERLPSA HTCFNQLDLP EYSSKEQLQE RLLLAIHEAS EGFGFG
//