ID   A0A067JTS0_JATCU        Unreviewed;      1171 AA.
AC   A0A067JTS0;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN   ORFNames=JCGZ_20185 {ECO:0000313|EMBL:KDP27361.1};
OS   Jatropha curcas (Barbados nut).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Jatropheae;
OC   Jatropha.
OX   NCBI_TaxID=180498 {ECO:0000313|EMBL:KDP27361.1, ECO:0000313|Proteomes:UP000027138};
RN   [1] {ECO:0000313|EMBL:KDP27361.1, ECO:0000313|Proteomes:UP000027138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. GZQX0401 {ECO:0000313|Proteomes:UP000027138};
RC   TISSUE=Young leaves {ECO:0000313|EMBL:KDP27361.1};
RX   PubMed=24837971; DOI=10.1371/journal.pone.0097878;
RA   Zhang L., Zhang C., Wu P., Chen Y., Li M., Jiang H., Wu G.;
RT   "Global Analysis of Gene Expression Profiles in Physic Nut (Jatropha curcas
RT   L.) Seedlings Exposed to Salt Stress.";
RL   PLoS ONE 9:E97878-E97878(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR   EMBL; KK914851; KDP27361.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A067JTS0; -.
DR   STRING; 180498.A0A067JTS0; -.
DR   Proteomes; UP000027138; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR045344; C-JID.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11017:SF305; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF20160; C-JID; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027138}.
FT   DOMAIN          21..180
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          553..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1171 AA;  133344 MW;  E65FB82A4E401F7E CRC64;
     MAAAPRNQEP STSSSKPSFR WTYHVFLSFR GGDTRKNFTD HLYTALVQAG IHTFRDDDEI
     ERGENIEQEI EKAIQESRIS VIVLSKDYAS SRWCLDELVM IMERRRTVGH IVVPVFYDVD
     PLQVGNQIGS YGAAFARHEI AFKEEMEMVD GWRKALREVA DMGGKPQFIQ NIVKEVGNKL
     NRIVLNVAPY LVGIDSRIAD INWWLQDVSN DVGIATIYGV GGIGKTTIAK IVYNQNYDKF
     DGASFLANVR EISEKSNGLV RLQRQLLSDL LKGKTNKIYN VDEGIIKIRD AICRKRILLV
     LDDLDQLDQF NAIIGMWEWF SPGSKLIITT RHERLLRVRE VRNMFRVHEL DDKEALQLFS
     WHAFGQDHPT EDFKKQSKRA VDHCSGLPLA LQVLGSSLSG KSTDVWESAL QKLEAIADSK
     IQKILKVSFD SLQDDHDKNL FLDVACFFTG MDKDYVFSIL DGCKFYTVVG INNLIGRCLL
     TINEANKLMM HQLVRDMGRE IVRQESPEDP GKRSRLWHNK DAFNVLRENT GTETVKGLIL
     NLQMLKEDNS GDTNAEINHF EDSGHESTLP DQENDSKRRH LGFFPWKPMN NDLSKSFYEV
     NLKTKAFARI DKLKLLQLSN VKCSGDYGDF PKGLVWLFWR GFPLKFIPNN FGLEKLVVLD
     MRNSNLLNAW KGTRFLVALK ILNLSHSRSL VKTPNFIGIP FLEKLKLKDC INLIELDESI
     GNLQRLVLLN LRDCKNLKRL PAEIGLLESL EKLNLIGCSK LDQLPEEMSK MQSLKVLYAD
     GTALSPLQSR NAPWYSTFWS WLLPRKSPQS INFTLALLPS YLINLSLADC NLLDTAIPYD
     LSSLRSLESL DLKGNPIHSI PESINSLTTL QYLCLDKCTK LQSLPNLPTS LEELKAEGCT
     SLERITDLPN LLSTLQVELF GCGQLVEVQG LFKIEPIINM DMEMMNNLGL FNLTCLGSIE
     MTMFNAMANR ERRTLPQVLQ ECGIFSFFIA GSEVPYWFSH KSIGSSISFT VTPTSGHTIR
     GLNLCIVYAR DDEVFWLHAA GHYAIINNET KGIIWSYSPT FYGIPEENED MVWLSYWKFG
     DELEVGDEVN VSVRMPSGFY VKECGIRIVY EQDKKDTEIN SKSIAENNSF WHQNITDRDL
     SPYQVGHSVY FLHHHPFTTP DEILKLASLQ L
//