ID A0A067NL90_PLEOS Unreviewed; 643 AA.
AC A0A067NL90;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0000259|PROSITE:PS00624};
GN ORFNames=PLEOSDRAFT_1047763 {ECO:0000313|EMBL:KDQ24351.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ24351.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; KL198011; KDQ24351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067NL90; -.
DR STRING; 1137138.A0A067NL90; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1047763; -.
DR HOGENOM; CLU_002865_7_2_1; -.
DR InParanoid; A0A067NL90; -.
DR OrthoDB; 3714148at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..643
FT /note="Glucose-methanol-choline oxidoreductase N-terminal
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005406861"
FT DOMAIN 331..345
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT ACT_SITE 573
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT ACT_SITE 616
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT BINDING 58..59
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 643 AA; 70838 MW; A014B79312C3A3B6 CRC64;
MKLLAGSAGL AALFLVLHKL LVSSNKLSAK APTKKNHLVA NLDELDSEYD VIIIGGGTSG
CVLASRLSED PNIKVLLLES GGSGKALLFT RIPSAFGRLF HNKNYDYDIR TEPQVHAQGK
TKYWPRGEML GGCMSASRLM AQYGAPGDFD QWAETIGDDS WSFKNFAKYF RKFEHFVANP
VFSPYTSFSS PDPSEKEEEI GLTGPVEVGF FNYVSETSKS FVRSCINVGI PYTPSFNGAS
GTAGVSRVMT YIDSNGTRVS SESAYLTDEV LSRPNLTVAI YAHTTRILFS EPENGNPRAI
GVEIASTKDR DVAEPKKYKV FAKNEIVLSA GAVHSPHILM LSGIGPSEHL SAHNIPTVVD
LPAVGANLVD HPIVDFIFKD KMGVSLSFLK PANVMDRLKS MKALIQYTIF KRGPLCNNMG
EAAAFVRTDD PSLFPKDDFK EELEDSTPSK DSPDLELFCT PLGYREHGAF IFDVHTYALH
VYLLRPTSKG YIRLLSNHPF DNPSVDPNYL QTSADIYKLL RGARLCLRLA HTEPLSSCLT
HSERRSDLDH FLHEKTDDEL LEIIRQRVET VYHPACSCRM AKKEDGGVVD AKLRVYGVDG
LRVCDASAFS YVVSGHTAGA CIAMAEKLSD EMKAELKANL EEF
//
