ID A0A067NYJ2_PLEOS Unreviewed; 597 AA.
AC A0A067NYJ2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0000259|PROSITE:PS00624};
GN ORFNames=PLEOSDRAFT_1031724 {ECO:0000313|EMBL:KDQ32964.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ32964.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; KL198004; KDQ32964.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067NYJ2; -.
DR STRING; 1137138.A0A067NYJ2; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1031724; -.
DR HOGENOM; CLU_002865_6_3_1; -.
DR InParanoid; A0A067NYJ2; -.
DR OrthoDB; 3215324at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0140907; F:flavin-dependent halogenase activity; IEA:UniProt.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..597
FT /note="Glucose-methanol-choline oxidoreductase N-terminal
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001646208"
FT DOMAIN 303..317
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT ACT_SITE 532
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT ACT_SITE 576
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT BINDING 262
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 597 AA; 64626 MW; CD81AA88C845522A CRC64;
MLLSISSLLA LLLPTVLGAI YESASELPSH NFDFIVVGGG TAGNVIANRL TENPRFSVLV
LEAGPSYVGT LALIVPGLET NNLPLPNPHN WNFSTVPQAG LNGHTVNYIR GFILGGSSAV
NAMYYTRGPA DDFDKYANLT GDQGWSWNNL QTYIQKNERW LEPTDPLTAK DRFDSRFHSS
TGMNFVSLNK LVHTTDSRMI QTTKDFPEDF PFNLDYNSGN PLGVGWLQAT IGNGVRSSSA
TSYLAPEYTA RKNLHVLVHA HVTRIREGIS RSKRFSTVEF MSQSGDGPTV RVTASKEIVL
SAGAFGTPQL LMLSGIGDTQ ELRALGIDTV HHLPSVGKNM SDHPKLGSLW SVNSTLTDEE
FFRNETLFQE VYEQWNRSRS GLLADAGATH LGFFRLPTNS SIFSSVEDPA SGPTAPHTEM
VFMVIATLDG VRPPLASGNF FSIGTAVVSP TSRGWLRLKS ANPFDPPLIN PAFLDTGFDV
FAMRSAVKLA KRILASPAWA GWIIGPAGAL ADANTDEELD EYARNNTGTT CHAVGTAAMS
AVDASFGVVN PDLRVKGVDG LRIVDASIFP FVPGAHTQAP TYIIAERAAD MIKEFWA
//