ID A0A067R3H7_ZOONE Unreviewed; 1049 AA.
AC A0A067R3H7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Protein toll {ECO:0000313|EMBL:KDR13629.1};
GN ORFNames=L798_12483 {ECO:0000313|EMBL:KDR13629.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR13629.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR13629.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR13629.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KK852931; KDR13629.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067R3H7; -.
DR STRING; 136037.A0A067R3H7; -.
DR EnsemblMetazoa; KDR13629; KDR13629; L798_12483.
DR eggNOG; KOG4641; Eukaryota.
DR InParanoid; A0A067R3H7; -.
DR OMA; EYELNCP; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00013; LRRNT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1049
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001644663"
FT TRANSMEM 800..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 851..987
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1049 AA; 117464 MW; 5D64B56DE4536535 CRC64;
MLVTMRQLML AAVLAVNTVS SDNSCPVLRK CRCDKNVKGD LDLWCSHVPQ KVLLHAKLVP
ENMLNLQCLS MTWMDYELLS GLNVGSIPLV AFTFCPLPNM SLYQMLLSVG ASGVESLVFQ
NGNLSDPLES SFLEGLTNLK TLILHSNGIT SLPEELFQGM TALQYLDLKD NALQLPLHVF
DSLSNLQTLE LGGNQMTRLE VGIFRNLSRL ARLNLWGNNL QNLTQDVFTG LSSLEFLDLS
SNKLTSISAD LFHMMPKLKE ITMPGNNFTS LPHDLFTSTS SLTKLGLYNN RQQLQHIPPG
LLANLTNLLE VYLNMCGITQ VPGDIFWGSL AIVNISLHGN LLTTLPEELF RDTVSLRNLK
LGNNQLQTLP DGVFFGLGKL EALELDHNHL TSITGDLLKD LRRLERLNLE HNKLQHIAVR
AFTHVPGLKD LTLSHNRLSL SGPQTEIGEV QSVLSACVQL EKLFVSNNSI KTVFSDWVLT
LLNLRTLDLS HNLISNLTLE DMQFLSNSIT VDLTYNSISS VDLQNLELVA SAQVPHRHLP
KREILLEGNP LMCDCKLYDL LRYFEDRLEP EARSMFEIIP GNLTCAAPPE WSGIAVNHLS
SVKIQCPLPQ LGDCPNPCTC SGRPADSALV VDCSGLKLSQ SPASLPDPLK LNKSVLWPRR
LRLNHTELWL KRNGIVKFPW NTAPGYSRVT KLYLSYNNIS TFVAEQVPPH LQVLELDHNN
LTQLDASILQ AFGNKTGLQH ITLHANPWHC DCEARGIITF LQEHFTQVAY LPNVTCGDGS
GRSLSNLTFS DICPVSSTTI VTMSIIIALS GIIVGISVAL YYYYQNEVKV WLYARGLCLW
FVTEEELDKE KLYDAFISYS HRDEEFVVNH LVPGLEGGTT QFKLCLHYRD WIAGEWIPNQ
IARSVEDSRR TLVVLSPSFL ESVWGRMEFR TAHSQALSEG RARVIVLLYG DVGPMEQLDP
ELRAYLSMNT YVKWGDPWFW DKLRYALPHP QKVGERGMEL NPRRKVKDDK LELINPSIPP
SATTTTFTHT PMTQSSIPFR AAPVTNGDT
//
