ID A0A067R619_ZOONE Unreviewed; 1031 AA.
AC A0A067R619;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
DE Flags: Fragment;
GN ORFNames=L798_06627 {ECO:0000313|EMBL:KDR18646.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR18646.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR18646.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR18646.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
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DR EMBL; KK852680; KDR18646.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067R619; -.
DR STRING; 136037.A0A067R619; -.
DR EnsemblMetazoa; KDR18646; KDR18646; L798_06627.
DR eggNOG; KOG3522; Eukaryota.
DR InParanoid; A0A067R619; -.
DR OMA; HQNDKCD; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135}.
FT DOMAIN 143..331
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 426..456
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KDR18646.1"
SQ SEQUENCE 1031 AA; 113931 MW; 413DF976AB6B7F02 CRC64;
PFAPSDLSDS EGRTGGSAGS ESRSPHTPRR YSKRPLRGPY GQMLEAEMSK AETNRMSKLQ
LEFLEKYVAN IPYSAPHGET QSLQQQPQQP QQQFVCHQRT TSSPSQLEGY SGTSPRPELL
AELLRGSSER MYNGSSVQHG QDTRTHVVVE IYDTERSYVE SLQILVMKYL QPLKSPENAG
LVDSAVVDAM FYQIPAILAH HEVFLEELRK RLQHWDIKQK VGDVFLDVFT KKAVIETYTL
FLNNFKTAKE AIKATCQAKP AFARFLEAMA REHKGKLALD CLLIMPVQRI PRYELLIQTL
LKHTDPSHPD HQLLYEAQRE VHDLAMKINC TERETLKELE ALIEGLINLV AADRTFIRHD
LVTMVSGQGT RKERALFLFS DLLVITSIKR RSGTIRKPST SCPGSVASTL EANKYKLLMR
IPLDDLEIVK AKDENLRRML NEMENLAEDV TILNQINDLI MSLHCPHGQL EEVIREMLSS
VNKQLIERQT SDSQLSYLEL TLSTQNGIEN LSVVFTKPDK RTSWEESFNE AKQKLALSAD
RRPSPEFLSP LPIRKTRAGL QFTCAAPTLG LNAYNMRDVW VCNSDGYVGQ VCVLSLQPEP
TVISCNGVCN ARILCIASIP TGIMGLSSSC SIGQPFTNSK AGISISVEDT DESGGNTVQL
DSSSSSEDED EGEEGMPGPG ISISVEEDPK RIRSASDSLV CETSIVTEDT DSLQPTMWLG
TEDGCIHVYN CSDNIRIKKN KVKIQHGSSV HSIIYLDNRV FVSLANGDIT VYVRDHNGGW
NTTDPFTVSV GTAATPVTRM LPIAGKLWCG CHNAIKILNT ASLEVEHSFQ VNSDSSRAVT
CIALSGLGVW ISLQNSAVVR LFHAMSYEPL CDVNVAPAVT KMLASCDDII RQHKAACLRV
TSLLACKDLL WIGTSAGVIL TMPLPHITPA TTKLANVPNA TGVPHGHTGH VRFLTFVETV
PAQSGDSLMV RSSAHHRHSM KSKPELQSSS NTSVKLLVIS GGDGYEDFRT SSVSEVAGRE
DSTNHLLLWH V
//
