ID A0A067R6Q2_ZOONE Unreviewed; 376 AA.
AC A0A067R6Q2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 {ECO:0000313|EMBL:KDR18038.1};
GN ORFNames=L798_07714 {ECO:0000313|EMBL:KDR18038.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR18038.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR18038.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR18038.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; KK852704; KDR18038.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067R6Q2; -.
DR STRING; 136037.A0A067R6Q2; -.
DR EnsemblMetazoa; KDR18038; KDR18038; L798_07714.
DR eggNOG; KOG1430; Eukaryota.
DR InParanoid; A0A067R6Q2; -.
DR OMA; LTYGECD; -.
DR OrthoDB; 3675908at2759; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:KDR18038.1};
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 11..295
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 376 AA; 41308 MW; 79611EFCC0195020 CRC64;
MAEESSSEVI LVTGGSGFLG QHIVKLLQEK DPKVREIRIL DLKPYVNHLD HKEQKLMKMI
VGDIVDLEAV REAFRGVDCV IHCAALVSYS FPPDKEALDR VNVTGTRNVV SLCVEMGVPR
LVFCSTSEVT LTPYMGGIHA MIINQTESKA LAPSCDKGWK LLLPGYPASK LGAENIVLAA
NGRPLSNGHG QLHTVVLRPT LLYGEQDPHL VPSLIHLSEK MDSSLVRFGG SGGRQQMTYV
GNAAWAHLCA KDKLLVTCPG GGIAGLPIFI TDDTPVDDLL IFAQKVTTRA DLPPRCCLSR
WYIPALLAYM VAAIIELVVM MTRIPLSVPP CGIVAYLGSI VLYNRLRASL HLNYMPIFQP
DETYSRSNKY YTKKKL
//
