ID A0A067R932_ZOONE Unreviewed; 654 AA.
AC A0A067R932;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=L798_10668 {ECO:0000313|EMBL:KDR14977.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR14977.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR14977.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR14977.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; KK852854; KDR14977.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067R932; -.
DR STRING; 136037.A0A067R932; -.
DR EnsemblMetazoa; KDR14977; KDR14977; L798_10668.
DR eggNOG; KOG1116; Eukaryota.
DR InParanoid; A0A067R932; -.
DR OMA; TIWTLYR; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KDR14977.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 178..324
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 654 AA; 72899 MW; D9C52F4E737F59AA CRC64;
MDGGGVHGTP VLEETFYILS KKNTVYRVKL TEKGLSLQKE SNGNTKIEVI RIDDIVGCRC
MRSKRRSGGS CACHPNAIRR NNVRVVEENS SEQDEKDVSA YLYIYAYVLK KYRVKSGQKR
ERMTITLRFR SFDKYEDNMR EAQKWRLAVK CLVKNKSIPR GILASEDSQV TAQSFFHLEE
RKLLVLLNPK SGPGKARELF QQRVVPVFAE AEIGFDLYVT KHANYARDFV RTKDIYQWRG
VVVVGGDGIV FEVINGLFER EDWQTAVKEL PVGVIPCGSG NGLAKTISYA VEEPYDQNPV
LISTLSVIKC RCAPMDLVRV ETKSQFLFSF LSVGWGLLSD IDIESERLRA IGGQRFTVWS
VARLIGLRTY RGKLWYLPVA GCRVQSAQTY MSGLTRSVSH CAETGSKPRD IFPATSYTPV
HPSHSCHDSI NSRYRPLQEV GCDDPVTDSL SLETSLGPAL EDLRDGDEFG RPRLDSYYSA
ASRRSTYFST AGSDYRSVAD NCSYMGVHGG GDIQPRRPNS NVRMYGPPSQ LPALTQPVPD
HWSSIEGDFI LVHASYQSHL GSDCLFAPNS KLADGIIWLL VIRAGISRGQ LLQFLLGLSS
GSHLLIPQAE MIPVTAFRLE PETSGGHMTV DGEVVDYGPI QAELMPSLAN IMSM
//
