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Database: UniProt
Entry: A0A068NHN8_9ACTO
LinkDB: A0A068NHN8_9ACTO
Original site: A0A068NHN8_9ACTO 
ID   A0A068NHN8_9ACTO        Unreviewed;       567 AA.
AC   A0A068NHN8;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=FB03_06590 {ECO:0000313|EMBL:AIE82972.1};
OS   Actinotignum schaalii.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Actinotignum.
OX   NCBI_TaxID=59505 {ECO:0000313|EMBL:AIE82972.1, ECO:0000313|Proteomes:UP000035032};
RN   [1] {ECO:0000313|EMBL:AIE82972.1, ECO:0000313|Proteomes:UP000035032}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCUG 27420 {ECO:0000313|EMBL:AIE82972.1,
RC   ECO:0000313|Proteomes:UP000035032};
RX   PubMed=25189588;
RA   Kristiansen R., Dueholm M.S., Bank S., Nielsen P.H., Karst S.M.,
RA   Cattoir V., Lienhard R., Grisold A.J., Olsen A.B., Reinhard M.,
RA   Soby K.M., Christensen J.J., Prag J., Thomsen T.R.;
RT   "Complete Genome Sequence of Actinobaculum schaalii Strain CCUG
RT   27420.";
RL   Genome Announc. 2:e00880-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP008802; AIE82972.1; -; Genomic_DNA.
DR   RefSeq; WP_026428913.1; NZ_CP008802.1.
DR   EnsemblBacteria; AIE82972; AIE82972; FB03_06590.
DR   KEGG; asg:FB03_06590; -.
DR   KO; K02313; -.
DR   Proteomes; UP000035032; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035032};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035032}.
FT   DOMAIN      257    391       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      469    538       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     265    272       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   567 AA;  62036 MW;  202DD9ABAFDE7070 CRC64;
     MAEMNPARDA WLAALELLRM QGDLSDSQSA FVRMAHPLAT AEDIFMIVVG SEFVKNWIEE
     HVADLMTGAL SNILGHSIRL VISIDPSVNE SPLPATERRE PRPVEAAPAP RRAETPTALS
     PDSEWNKSAT YRDFTLEEPG AFPDAPGEPV APAAPSALNT THASAPHTAA SHVPGSHVNA
     PHATAPGETT EPTSLATQTM ASGEEKIYGN SADPSFAAMS TAAGLNPKYT FDNFVIGDSN
     RFPTATSLAV SEAPGTTYNP LFLYSDSGMG KTHLMHAIGN YAISLYPNIH VRYISAEEFT
     NAFINAVRDG RQSEFKDSFR KVDILLIDDI QFIGGRDTTV EEFFHTFNAL TNSNKQIVIT
     SDVAPNLLNG FEERMLSRFN SGVVASIDRP NLETRIAILE KKAHVDGISV PREVHEYIAT
     HMTTNVREME GALRRVTAFA DLSKQPVSLT LSEMVLKDLI TNPDSVDIKP SLIMAQTANY
     FAITIDDLTS ADRSRIPVTA RQIAMYLCRE MTDLSLPKIG SLFGGRDHTT VMHAYRKIDK
     QMAERQTTYN QVSELSVRIK QAASQAE
//
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