ID A0A068QXZ9_9GAMM Unreviewed; 662 AA.
AC A0A068QXZ9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=XPG1_0010 {ECO:0000313|EMBL:CDG19669.1};
OS Xenorhabdus poinarii G6.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=1354304 {ECO:0000313|EMBL:CDG19669.1, ECO:0000313|Proteomes:UP000032735};
RN [1] {ECO:0000313|EMBL:CDG19669.1, ECO:0000313|Proteomes:UP000032735}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G6 {ECO:0000313|EMBL:CDG19669.1,
RC ECO:0000313|Proteomes:UP000032735};
RA Genoscope - CEA;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO704551; CDG19669.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068QXZ9; -.
DR STRING; 1354304.XPG1_0010; -.
DR REBASE; 88908; M.XpoG6ORF10P.
DR KEGG; xpo:XPG1_0010; -.
DR HOGENOM; CLU_020164_2_1_6; -.
DR Proteomes; UP000032735; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PIRSF; PIRSF015855; TypeIII_Mtase_mKpnI; 1.
DR PRINTS; PR00506; D21N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CDG19669.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CDG19669.1}.
FT DOMAIN 131..461
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 662 AA; 75915 MW; 7B284499EF426434 CRC64;
MRFSPLAING IPLMTIEKIT PNYPESKSAD ITQNNIDQLK QLFPEVFSEG KINFDALKAV
LGEAVDDSDE RYNFTWHGKT RARQIAQTPS TGTLRPCKEE SVNWDTTENL FIEGDNLEVL
KILQKSYHKK IKMIYIDPPY NTGKDFIYRD NFNDNIKNYL ELTGQVDGEG RKIRTNSDTS
GRYHSSWLNM MYPRLKLARN LLKDDGLIFI SIDENEIANL KSICCEIFGE DNILGVITNI
NNPKGRSDDK FIATAHEYLL VIAKNSSLAR TYGFEPDEKI TKRYNKIDEN GKKYRDIDLR
KTGDADRRED RPDMFYYFYF DEVLNCLTVS KDRINSDLIE IKPVKDNGAD GRWRWGFDTA
KNRINDIYPK YMPTKKMWGI MEKDYLEGRP PVKPTSAWTH KDVNSERGSE QFIELGFEKE
VFSRPKPIGT ILRAIKIGSI PEEKSIVLDF FAGSGTSAHA VFEAVKIYNK NLTFIMVQLP
ELLDENKKEN KSVIEFCKEN GKPYFLSEIT KERIKRASEK TGVNTGFKVF KLDETNIRSW
DANFDNLEPA LKLALKSIKD DRSVEDILYE ILLKYGIELT TRVEEVTVEG KKIFIVGTGA
LIVCLDDDIT EQVIEGIAKL KEKLNPESTQ VVFKDQGFAD CIVKTNAIQI LKQYGINDVK
SI
//
