ID A0A068RL77_9FUNG Unreviewed; 742 AA.
AC A0A068RL77;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=LCOR_02172.1 {ECO:0000313|EMBL:CDH50460.1};
OS Lichtheimia corymbifera JMRC:FSU:9682.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Lichtheimiaceae; Lichtheimia.
OX NCBI_TaxID=1263082 {ECO:0000313|EMBL:CDH50460.1, ECO:0000313|Proteomes:UP000027586};
RN [1] {ECO:0000313|EMBL:CDH50460.1, ECO:0000313|Proteomes:UP000027586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMRC:FSU:9682 {ECO:0000313|Proteomes:UP000027586};
RA Schwartze V.U., Winter S., Shelest E., Marcet-Houben M., Horn F.,
RA Wehner S., Hoffmann K., Riege K., Sammeth M., Nowrousian M., Valiante V.,
RA Linde J., Jacobsen I.D., Marz M., Brakhage A.A., Gabaldon T., Bocker S.,
RA Voigt K.;
RT "Gene expansion shapes genome architecture in the human pathogen
RT Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient
RT terrestrial Mucorales (Mucoromycotina).";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDH50460.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CBTN010000006; CDH50460.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068RL77; -.
DR STRING; 1263082.A0A068RL77; -.
DR VEuPathDB; FungiDB:LCOR_02172.1; -.
DR OrthoDB; 1387014at2759; -.
DR Proteomes; UP000027586; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000027586}.
FT DOMAIN 306..545
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 77..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 236..263
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 85..119
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 82273 MW; C304292958129F83 CRC64;
MQHVEATLLS ATRLEEEGKV KDAYMSYMDI TQQALQGLYD IKFIHSSIVS QPKQYTALIS
AMHTCLTHIE HIIDTHSPSR NQIPEPIAPK SPRPPLPPKP SRIQKPVIPP KPLRPTPSRP
ASPTKDLDHQ PPVPKPRIPQ RPLPDDIRPV SAPQSPGNDP NNIGHYRRPY SETPPHDDDM
ATKVMHNRAV AEGKVDPTHL VPAQTNAGDS LSPPSATSLN TDHLPIIPAP PLLTTHRILQ
ARLDELESTI KDCRQRKQQT SGNKAAELDN TILQYTGAAA DVKHTLNRVR TLYMSAATIP
TILQFPAHMI AYQVTLIESA IFNAIPPKAL LEHSAKHPHP RIVASTDFFN YLTRVIEHTI
LLPQEASSRA QHINHWIKVA SKCLDLNNYQ TLKAIVSALG TPPVQRLRRT WAYIPKKSMT
KLEGLNELMS ESDNYGKYRE HMGMVNASVI QGRSAANIRA EHYTKPTVPF LGTFIHDMTY
MLAAANNNKA AAMDDPRVAA VLDIISSFQK GPAYTAVPPN WFVKAAQKHH HLRPAALSSA
LLHRSASGIG RFSGGMFGGN NNNNDDDAAN KENMVEEDSL EEQQQTITQY LLMRSWVNQN
TIDELSVLRE PPRQQQQPGS SSYRSTTGSN HHTSSVISNT SSLMRFSTGS ISQSTLTGGS
RATSMEDYSP DASDDPDTIK VWHRHSHDDD HHHPAAVNKA PHIPPRPPPR SSNKDDDEKD
FKAALAQRIQ AQVDARHPPP HP
//
