ID A0A068S627_9FUNG Unreviewed; 1099 AA.
AC A0A068S627;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=LCOR_08365.1 {ECO:0000313|EMBL:CDH57425.1};
OS Lichtheimia corymbifera JMRC:FSU:9682.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Lichtheimiaceae; Lichtheimia.
OX NCBI_TaxID=1263082 {ECO:0000313|EMBL:CDH57425.1, ECO:0000313|Proteomes:UP000027586};
RN [1] {ECO:0000313|EMBL:CDH57425.1, ECO:0000313|Proteomes:UP000027586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMRC:FSU:9682 {ECO:0000313|Proteomes:UP000027586};
RA Schwartze V.U., Winter S., Shelest E., Marcet-Houben M., Horn F.,
RA Wehner S., Hoffmann K., Riege K., Sammeth M., Nowrousian M., Valiante V.,
RA Linde J., Jacobsen I.D., Marz M., Brakhage A.A., Gabaldon T., Bocker S.,
RA Voigt K.;
RT "Gene expansion shapes genome architecture in the human pathogen
RT Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient
RT terrestrial Mucorales (Mucoromycotina).";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the
CC gene. {ECO:0000256|ARBA:ARBA00024691, ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDH57425.1}.
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DR EMBL; CBTN010000046; CDH57425.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068S627; -.
DR STRING; 1263082.A0A068S627; -.
DR VEuPathDB; FungiDB:LCOR_08365.1; -.
DR OrthoDB; 24955at2759; -.
DR Proteomes; UP000027586; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF12815; CTD; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 5.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:CDH57425.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Protein biosynthesis {ECO:0000313|EMBL:CDH57425.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000027586};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 145..235
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 239..266
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 391..418
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 443..470
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 663..690
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 758..952
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 1038..1065
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..35
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..84
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 120228 MW; 6DD2FD53CDDA7ECD CRC64;
MKRQDEYEDD VPFDEEDEDE DFEDEEDEDE EEEAVCINGE RPRKRAANPF IDEMALVDED
EEEEEEEEEY GREDGFIDEE PEEIPSEAAM QRRHLDLDRR RREMEGMDDE QVAAFYAQKY
GGRRAQAFKS SEEIPQQLLL PSVTDPNLWV VKCKPGKERD IVLGIMKRYF DRQYSDQPLE
TFSAFARESL KGYIYIEARR LAHVQQAIAN IPNIFQTTLQ LVPIKDMVDS INIPKKETDI
PVGGWVRVKR GVYTGDLGKV LEVSDSQDTA VIKLIPRLAL EPQEEEIERK RKKGSSATRP
PPRFFNPERL SKRHIASLQK KGPYWVLGTD SFRDGYLEKN MKVSSLQIED VSPSLEEITR
FIGDSGGDGD RALDLSAASL QSVNDAQATS LLQTGDTVEV IEGDMIHSVG TIDNVSDSSV
VVSLNFGGYA KQVTLPAKQV RKKFNAGDHV KVIHGQRKDE SGMIVKVDGN VVTMLSDISM
DEVQVFAKDL REAADVTLGK TVMGNYELHD LVQIDFHTVG VIIKVNKNSV KVLTQNGDVR
TLEPHLITSK LDSKRAIATD ANGNSITAGA TVMEARGERR TCTILHVYRH LVFLHSRENM
VDYGVWISPT RSVISVAAKE RPNISQQKRT QQPNGPNFRG GFDGRGRGRG GRGGFFGGRG
GRDHLVSKTV RITQGPHKGY IGIVKDSTDT MARVELHTNC KVVNVDKTKL VLVDGNGGTL
GPVVSDTRGA SDFAAPRPMA TPKRYGDGAM TPRHYSDGSR TPRHLASGAQ TPAWGMNNRT
PNPYSSDNSR SSAWDAGAKT PNPYASSSYA DGSKTPAWDS GSKTPSWKAE TPRWSSSGGR
TPGYNDYGNK SPTWSSRYDD RETAPTPAPH TLAPSTPAAS SNNVAPSPAP YPQTPGANYP
QTPYDSAPTP YDGAPTPGVN LAPATPAAVN APTPAAHMLS APTPGGYIPS TPAGTVQPQT
PFVPAGGDYG TVDDQNEDSD DWPIEDIEVK LTSSHGSGQK GQLASIISVD HNGRTCTVRM
NEGGAQEHIP FTKMEPVRPS KRDPVKVLLG QHRGGIGALI GVDGQDGILR LRGQGPAFKF
VSINAVGKYT GDEALDGNH
//
