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Database: UniProt
Entry: A0A068X4C0_HYMMI
LinkDB: A0A068X4C0_HYMMI
Original site: A0A068X4C0_HYMMI 
ID   A0A068X4C0_HYMMI        Unreviewed;      2143 AA.
AC   A0A068X4C0;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   SubName: Full=Sodium leak channel non selective protein {ECO:0000313|EMBL:CDS27267.1};
GN   ORFNames=HmN_000164100 {ECO:0000313|EMBL:CDS27267.1};
OS   Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=85433 {ECO:0000313|EMBL:CDS27267.1, ECO:0000313|Proteomes:UP000017242};
RN   [1] {ECO:0000313|EMBL:CDS27267.1, ECO:0000313|Proteomes:UP000017242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nottingham {ECO:0000313|Proteomes:UP000017242};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
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DR   EMBL; LN906329; CDS27267.1; -; Genomic_DNA.
DR   GeneDB; HmN_000164100.1:pep; -.
DR   Proteomes; UP000017242; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000017242};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017242};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     43     60       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     66     87       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    207    229       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    412    432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    452    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    544    566       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1029       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1049   1069       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1081   1098       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1144   1166       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1257   1282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1352   1369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1390   1415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1421   1440       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1452   1471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1483   1509       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1573   1597       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       51    360       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      414    643       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1012   1285       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1353   1606       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   2143 AA;  240618 MW;  DDABFF433F0621CA CRC64;
     MFKLDKDASR PRETLPILSG LNFPTDDVEP HSLRWIYTRW AKMLLRSAAL ISLISVSANT
     PRTFEYVPSL MYVTFAVDIM VACLLTVEMI TKMCIQGLVA PSTNNSMGVN VDSSSRRNRA
     YFQQSWNCFD TFMVICLWAS VALQCFEIRA EWSGLDEEQK FFKTAGWLSV LRCPRPFILI
     RVFRAVLKLQ LPPARVNAIF QRSTHQIYNV SVFLLFFMSL YGLLGVQFFG DELNYHCADK
     SANESNLLKS NLAIPDAYCD PYAPESDNQC PKDMKCVRTV ARIADEGSYA SFEAFHVSMF
     TVYQASSQEG WVFIMYRAMD CLAPWKGVFY FLTMIFMLAW LVKNVFIAVL TETFAEIRVQ
     FQQMWSPRIA TDTDFSKIFQ FDGTSWKLVP VHERKSRGLA PRFVEETLLK STGFNIGIML
     LVLANAITAA GQHFNHQRIR HDDSDGQFHL DGFYYAELGF TMVFNLEAAF KIWCLGWRAY
     WSRSLFKFEF ILCVGTTLHC IPKLYRTEFT YLSVMRIVRL IKASPMLEDF CFKIFGPGKK
     LGSLVLFTMC LLIITSTFSL QLFCYLQISD PTFDRFETFP KAFMSMFQIL TQKGWVAVMH
     DTMDVVRNEA VTTGVAIYFV FYHLFVTLIV LSLFVAVILD NLELDEDIKK LKQLKMREMS
     AETQQKLPLR LRIFEKFPNR PQMVKITRLV SDFLLPKIRD SFMRQFAAVS ALEEVEEEAV
     SEILAAATTI ASISASAALI PSSFGAAGPG IVSQSGVGLS AGKAQSYTGP GGGTSGQSGV
     VGGVSGSGSS GGWRSKAAET AAAISFSREI RRKVHGLHGE EKVRAIVYLL SESNKTRMLS
     IDQTTNANGR SLLSTQHHIR LERRSLRNRS SVALGTAFLG RDGAPMGISL SGGVGSVLGG
     GGVGLGELNA AFGLGIDSTG DSRTGLDNTG HYDIKVLQQK AQMAEIKRTQ QEEELRENHP
     LFDRPLFTLG RQSRLRRFCN LVVSARHKAS RSSSGNDNNG SSIHKMLGFI TYLDWVMLII
     TIASCISMSM ETPHKRLMNS PELKIGEYIF FVGMTIELGL KVLADGFIFT PNALLRDFGG
     FLDIFTYIVS LVFVSYFMRV EKLGPGSVGH LFMVLRCLRP LRIFCIVPQM RRVVYELVRG
     FREILMVTVL LVVFMFIFAV YGVHMFGGRL AICNDRNVTR KEDCVGVFRR ELSVSRMKSF
     KGDAPTILVP RVWANPRNFN FDNIGNAILA LFEVLSLEGW VEIRDVIKAR IGPTHVVYIH
     LFVFVGCLIG LTLFVGVVIA NYSENKGTAL LTVDQRRWLD LKGRIKLTQP LHIPPRPKLR
     PEPGQAQIST ETTFLRFRCL IYDITQHIAF KRAFAILVLL NSALLYCPFN EYGGEINPNI
     KTRYKVQVSL AMLFTLFFGV ECVMKIIALT FSGYWQSKRN RFDMFITILG VVWVVLHLGL
     RSTPENRIIS NNFGWLIQML RFFTIAGKYV TLKMLMLTVT MSIYKSLFIL TSMVVLMLVY
     GLLGVILFGS VKYGDNLGRH ANFKNAFRAI ILLTRIVTGE DWNKIMHDCM IQPPFCMMKE
     TFWETNCGNA QAALAYFCSF YVIITYVMLN VLVAIIMENF SLFYSNDEDA IMSYSDIRNF
     QQAWNIIDVN RKGMVKAYYV RFLLRLIPRD RVGFDLSKKR DKQLFKEMCY EVETLRGGRD
     KEVSFHDVLM VLAYRTVDIT KTLQLEELIA REDLEYAIEE EVARQTIATW IERCIFRKRQ
     KHGHLHFSMH SGSDRPASGQ SFEDPTKDSS NTNATKSSLK TRPSKIKFSR EEFATRADSV
     ENPPSASSNN QSPPASPTQH ILSPVSTTIR ATDSAVAKMA GFHDNCESRG QRSNGRFDSK
     SSQKTEIHLA DGLIPNSIGN KSQSTSPSPS SLGFVDSCTK SKQSSANANP VETEPHKGIR
     LSGSGGTFFR RRSMRSAKQH TPILSGVVED ADQITRHSLF SGAGMPAIQE AGIGQAKNSS
     IELNELGATS PGLSIPPGDK QFLESGASSV SGEHGGESFE KFGISDASRG SPYREKRGHV
     VSDELTDITV PLPSVVQTSC QDVKSWWMQQ IHPDCLATVG DRLDKPSSGG WEGSKESFVP
     SVVVTDRQTG RLRRNRRGGG ADKEPESMSF SNGKKRYVNE SVA
//
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