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Database: UniProt
Entry: A0A068XB12_HYMMI
LinkDB: A0A068XB12_HYMMI
Original site: A0A068XB12_HYMMI 
ID   A0A068XB12_HYMMI        Unreviewed;       830 AA.
AC   A0A068XB12;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   20-DEC-2017, entry version 12.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HmN_000239600 {ECO:0000313|EMBL:CDS29593.1};
OS   Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=85433 {ECO:0000313|EMBL:CDS29593.1, ECO:0000313|Proteomes:UP000017242};
RN   [1] {ECO:0000313|EMBL:CDS29593.1, ECO:0000313|Proteomes:UP000017242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nottingham {ECO:0000313|Proteomes:UP000017242};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; LN906333; CDS29593.1; -; Genomic_DNA.
DR   GeneDB; HmN_000239600.1:pep; -.
DR   Proteomes; UP000017242; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   Gene3D; 1.20.5.790; -; 1.
DR   InterPro; IPR027400; S_HR2.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017242};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017242};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    397    422       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    443    460       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    535    553       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    562    588       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    631    651       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    760    785       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       92    112       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   830 AA;  94960 MW;  ED904C2C433C9A5C CRC64;
     MRLSQLLLHI DSAYMCIVEL GELGVVQFRD INADRNIFQR NFVNEVRRCD EMERKLRFML
     NEIQVNKLLL YESHDIPEAP APREMIDMET TFEKLENETK EVNASIGNLR QTYFELQEMK
     HLLRKTQIFF DEAHHTASLS TDENLGLLKE EGGQTTYSGG DLHLGFVAGV ILREMLPAFE
     RMLWRACSGN VFLKQAEIEL PIEDLLTGEK VYKTVFIIFF QGDQLKSRVT KICEGFHATL
     YPCPESSADR RSMLIDVVQK IDDLETVMTQ TQQHRQRILE AAAKNLNNWF IRVRKMKAIY
     HTLNLFDLDV TTKCMIGECW SAVSDLDQIN LALCRGMQKS GSSIQPILNA LPTKDEPPTF
     HRNDKFTEAI QNIMDSYGVA KYREVNPALF SLASFPFLFA VMFGDAGHGL IMFLFALGMI
     IWENRLTALH IKEEIWNTFF GGRYIIVLMG AFSIYTGIIY NDFFSKSANL FGSSWYPDYD
     KHTIATRPFL QLEPRTSENI TDQMYAGQPY PFGVDPIWQI SNNKIPFMNS LKMKMSIIIA
     VFHMGFGVVL SFLNNKFYNQ SLMIWCVTLP QLLFLVSIFG YLTIVIFYKW SAFTADNATT
     APSLLIMLIN MFKFNYEVKG GPGDTFYSGQ AAIQSMLMIL AVSCVPWMFL AKPLILRYRH
     RRGIALDVET SNQSKPVDNG EIQKQPNGNS SGHGDHGENL ENFNFGECII YSAINTIEYC
     LGCISNTASY LRLWALSLAH AQLSEVLWSM VMRMGLQIDA YYGSAMLFLI FAAWASLTVF
     VLVLMEGLSA FLHAVRLHWV EFESKFYSGT GYRFEPFSFT TYINIPLDEL
//
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