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Database: UniProt
Entry: A0A068XDR9_HYMMI
LinkDB: A0A068XDR9_HYMMI
Original site: A0A068XDR9_HYMMI 
ID   A0A068XDR9_HYMMI        Unreviewed;       880 AA.
AC   A0A068XDR9;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   15-FEB-2017, entry version 12.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HmN_000212900 {ECO:0000313|EMBL:CDS28952.1};
OS   Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=85433 {ECO:0000313|EMBL:CDS28952.1, ECO:0000313|Proteomes:UP000017242};
RN   [1] {ECO:0000313|EMBL:CDS28952.1, ECO:0000313|Proteomes:UP000017242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nottingham {ECO:0000313|Proteomes:UP000017242};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; LN903010; CDS28952.1; -; Genomic_DNA.
DR   GeneDB; HmN_000212900.1:pep; -.
DR   Proteomes; UP000017242; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017242};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017242};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    430    454       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    475    493       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    562    582       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    589    615       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    658    677       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    813    836       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   880 AA;  100220 MW;  0AD6573E54853959 CRC64;
     MGSIFRSEDM QLSQLILHTD SAYNCIAQLG ELGIIQIRDA TPEVNAFQRK FVDEVRRCDE
     MERKLRYIEG EIMKDNMSIY EPDEIPEAPP PREMLELETT LDKLDHELRE VTYNAEQLQK
     SYIELTEIKM VLRLTQLMLE HNTLEVNTSL TGAEDVLVEV PETRESHGYI ELLPSDDFDV
     GFRQSGGLSS TTYRSHHIDF IAGTILRDRS SSFERMLWRV SHGNVYLRFA DLEGIEDPIS
     GQTLDKCMFL IFFQGEQLRT RVEKMCEGYH ATIYACPDTH EKRQAMLLDV TSRREDLQVV
     LNRTAEHRAR VLESAAERLR EWFYKVYKMK SVYHSLNLFN LDVTTKCMIG ECWSAVSDLD
     AVQMALRRGM ELSNSTLQPI LNRLPTTEQP PTFHRTNKFT AAFQAMVDSY GVARYREVNP
     ALFSVVTFPF LFAVMFGDAG HGLIMFLIAL YLVLWEKKLI AKKIKGDMWD MFFGGRYIIL
     LMGLFSIYTG FIYNDIFSKA TNIFGSSWYP LNNPTDAPLN ATSHAEDEYG MFAGYPYPFG
     IDPVWQVSQN LIVYTNSLKM KMSIIVGVIH MLFGIILSAF NYKMFKDTLS IYCSLIPEVI
     FMVSIFGYLV FTIFFKWIVF ETSDAPSAPS LLTTLITMMK FGYRNQSDSQ ILYTGQPVVQ
     SFLVILAIIS VPWMLLAKPI ILYRRHKVQS TVNAIRAAYG ETGTTDDPEI GNGTGDYAPF
     RNESSPTLDR SSRKSKSAGG NNSGGSDHGD SEEWNFSDIV VHQVIHTIEF CLGCVSNTAS
     YLRLWALSLA HAQLSEVLWS MVMSKGLNMD GHIGGVLLAF VFGFWAFLTI AVLVIMEGLS
     AFLHALRLHW VEFQNKFYEG SGYPFEPFTF ANIEKASIEQ
//
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