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Database: UniProt
Entry: A0A068XHX8_HYMMI
LinkDB: A0A068XHX8_HYMMI
Original site: A0A068XHX8_HYMMI 
ID   A0A068XHX8_HYMMI        Unreviewed;      2179 AA.
AC   A0A068XHX8;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 17.
DE   SubName: Full=Voltage dependent L type calcium channel subunit {ECO:0000313|EMBL:CDS31782.1};
GN   ORFNames=HmN_000387900 {ECO:0000313|EMBL:CDS31782.1};
OS   Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=85433 {ECO:0000313|EMBL:CDS31782.1, ECO:0000313|Proteomes:UP000017242};
RN   [1] {ECO:0000313|EMBL:CDS31782.1, ECO:0000313|Proteomes:UP000017242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nottingham {ECO:0000313|Proteomes:UP000017242};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; LN906330; CDS31782.1; -; Genomic_DNA.
DR   GeneDB; HmN_000387900.1:pep; -.
DR   Proteomes; UP000017242; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017242};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017242};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    140    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    355    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    511    532       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    544    562       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    637    659       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    711    738       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    921    940       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    991   1008       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1065   1087       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1177   1203       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1257   1274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1303   1323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1398   1421       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1482   1505       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1644   1678       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2179 AA;  248111 MW;  D0CC50D0296EE111 CRC64;
     MTRIASPEED YANSRSPIDC SAREGHGACS ASSSKPGMAS LGFLAASAMQ ERLQGSSQTS
     LNFHQPCYVH RPEQSALNPE NDPDAQPMKS GNKLLFIFSE ENYMVLLTIT ANCIVLAMER
     HYPSGDKSAL SERLEQTEKY FLGIFCVEAL LKIAALGFVL NEGAYLRSIW NIIDFVVVAT
     GLLAYILPNL NQPALRALRV LRPIKLVTGF ESLQIVLKSI FRAMAPLLQI CLLLLFAITI
     FAIVGLEFYS GGFHMTCFDE RNPDVLPDSI PNSKSLVPCN IGNESSKGFL NAAHGSFRCP
     SGYICKGYWE GPNFGITSFD NIGYAMLTVF QCITMEGWTD IMYMTFDAVG DRFSAFYFGP
     LIVLGSFFML NLILGVLSGE FAKEKERVEK RRAFLKLRRQ QQTEKEFGGY MDWIQHAEEV
     ILAEDTTSAD DRIRIIAARR RAQKERNKKN AKDFPSQEMT YEDSEMYSDT KGNLFNQQGF
     LLKSNKSRFE SCWRNEKRFR YAVRRLAKSQ LAYWSVIVLV FLNTICVTIE HYGQPVWLTT
     FLYYAEYVFL GLFMTEMLLK MYGLGFRLYF QSAFNIFDCV VITGSLLEII IALFHPDTSF
     GISVLRALRL LRIFKVTRYW ADLRNLVLSL LSSMRSIISL VFLLFLFILI FALLGMQLFG
     GEFNFEEGLP AQNFDTFVKS LLTVFQILTG EDWNSVMYNG IRSQGGTNGG GFIYCIYFVL
     LVLIGNYTLL NVFLAIAVDN LANAHDLNDA EQADKNEEKM VQPTPLVLLY CGLFDYRRTF
     AFVKCGFNEV KKEEAKAKGL DPSAIDLTDP SKARVLPWIR TPTKDNMWQE SQQCFYPRDP
     TIVNELNMQL GDQKPNGNYL LSNLTGERKV QNYISFESDE TGQRPDSEKG GHGKPVLPYS
     SMFIFAPTNG IRRFCHFVVN LRYFDLFIMI VICASSIALA AEDPVAENST KNKILEHFDY
     AFTGVFTVEM VLKVIDLGVV LHPGAYCRDP WNILDAIVVF CALVAFTMNR NALRLGKPAT
     SASAKNLNTI KSLRVLRVLR PLKTIKRVPK LKAVFDCVLS SLRNVLNILI VFVLFQFIFA
     VIAVQLFQGK FFYCNDASKL TPEECQGQYF DFNADGIPTT VWREWKAHGF NYDNVFYAML
     TLFTVTTGEG WPGVLKNSMD ATHQNQGPIE DYQQRMAIFY ITFFVVFPFF FVNIFVALII
     ITFQKQGENE LMDLELDKNQ KRCVDFAINA HPLCRYMPKN KRSWKYRIWR LVVSTPFEYY
     IMVMIALNTL ILMMKYHRQE RRPSVAINID TAQQNYHNYC NTLIFLNSAF TIMFSVECIL
     KIMAFGPKNY FRDRWNIFDF ITVIGSITDV LVSELQQSAF LSLGFLRLFR AARLIKLLRQ
     GYTVRILLWT FIQSVKALPY VCLLIVILFF IYCIIGMQVF GNIKNDPMTQ MNNHNNFQTF
     GSGILLLFRC ATGENWQEVM LDCDAGRECE GSGTSCGSKT TYLYFVTFIF FSSFLMLNLF
     VAVIMDNFDY LTRDSSILGP HHLDEYVRVW AEYDPTARGR IHHSDMYEML RNMEPPVGFG
     KKCPYRLAYR KLIRMNMPVD DNGTVQFTTT LFALIRESLG IKMGPAEIMD QRDNELRYSL
     LKLWPVQAKR MINILVPPDS ELVYQKMTVG KIYAGMLILE NYRMSKQPHD KDQLKSADLV
     ARFFGAVTHN VHRSARNSET EEDSIHTGRW KSPTRVITKR VPKANLPASN VNSSVVQAKS
     PDHHISHSAA ASAADGAQYN SVVPISPTED QEIGALSRSS DLSSIEEEEE IPTNVVEPLE
     PVRGIPIGRM SSRPFDAYPM NAVSWQREPP LPERFQQQGG PPTSLLPFRY YQGRALTEPY
     HGMITLGEKR PHDMSESMSI GSMSLQKYHS PDDAGGRSPI QPSAPKRIIL SEFRKPEDFS
     NVSQPQPKPV VPRLRYQLMQ RFSPTWQADH MRPYPISRVS NVDNPNRSSH HYPGFAKRGF
     VTSSLNPTQS NPINVDDYGA HYPHEYPRML ASSRPPPHST RRPVYINFPK LERSPTGSEE
     LESGGDILDE ESTQPILWST VPPWSTPLQP YFVSEGGEST FNPPHLPPLP PPPPIPLNSP
     PPLPPPPRIA NQSLDSIPLR TRATSHQFYQ HPYPYPHSHQ KLYVETGRPS FFTPLNPPDP
     RLPISYHPHN SHYPHYHLS
//
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