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Database: UniProt
Entry: A0A068XQZ2_HYMMI
LinkDB: A0A068XQZ2_HYMMI
Original site: A0A068XQZ2_HYMMI 
ID   A0A068XQZ2_HYMMI        Unreviewed;      1439 AA.
AC   A0A068XQZ2;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 2.
DT   27-SEP-2017, entry version 19.
DE   SubName: Full=Voltage dependent calcium channel {ECO:0000313|EMBL:CDS32307.2};
GN   ORFNames=HmN_000427400 {ECO:0000313|EMBL:CDS32307.2};
OS   Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=85433 {ECO:0000313|EMBL:CDS32307.2, ECO:0000313|Proteomes:UP000017242};
RN   [1] {ECO:0000313|EMBL:CDS32307.2, ECO:0000313|Proteomes:UP000017242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nottingham {ECO:0000313|Proteomes:UP000017242};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; LN906332; CDS32307.2; -; Genomic_DNA.
DR   GeneDB; HmN_000427400.1:pep; -.
DR   Proteomes; UP000017242; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017242};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017242};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    124    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    350    368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    421    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    533    559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    632       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    753    776       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    860    883       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       81    159       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      279    565       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      611    893       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      895    965       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   DOMAIN      966   1042       Ca_chan_IQ. {ECO:0000259|Pfam:PF08763}.
FT   COILED      153    181       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1439 AA;  163397 MW;  D40FC2ED843F07CF CRC64;
     MQVSHSNFPF LYANQVLGFS EKSHALSAQF NAKYRESALS SLPLHGDICS SWATTIRRWF
     QIKEIKTYCA NTKIFAFDDG QPSQHFDTFS KALLTVFQIL TGEDWNNIMY NGIRSQGGLS
     KGAFIYSVYF VLLMIFGNYT LLNVFLAIAV DNLANAQELT AVEEAEKKIA EQKRADELKE
     KFYQMGLLPN ENNLNSEMDL SNSIGDRLAK YYEDALTRGE ENSGGFHKDE KRGGDESGSD
     SSYMSRQDFG RAMLPYSSMY IFSPTNPIRR FCHFVVNLRY FDLFIMIVIA SSSISLAAED
     PVDERNPRNI ILEYFDHAFT CVFTMEMILK LIDLGVLFHP NSYFRDPWNV LDAVVVLGAL
     VAFFNRQADG GTGIGRKATS KNLGTIKSLR VLRVLRPLKT IRRVPKLKAV FDCVVSSLKN
     VFNILIVYIL FQFMFGVVAV QLFQGKFFAC SDLSKETPEE CQGYYISYEN SDIPEVRPRV
     WSARAFNYDN IGYAMLTLFT VTTGEGWPDI MKNSIDATGV SQGPKADYRQ HVAIFYVVFF
     IVFPFFFVNI FVALIIITFK EQGENELVDH EMDKNQKQCI DFAIHARPLC RYMPEDSKSV
     KYRIWQLVVS SPFEYFIMTM IALNTLILMM KYHRPEKSLR SILEADDDTK AYESYCASLM
     YLNTAFTGMF TIECLLKILA FGPRNYFRDR WNTFDFITVI GSITDVLVTS SQDTSFLNLG
     FLRLFRAARL VKMLRQGYTI RILLWTFIQS FKALPYVCLL IAMLFFIYAI VGMQIFGTIA
     VDDPTSQITA QTNFRTFGNA LLLLFRCSTG ESWQELMLSC DFPQRCTVMA SNAKSEEDGN
     SVSGGGNLLG GYNCGSAGTY LYFVSFIFLC TFLMLNLFVA VIMDNFDYLT RDSSILGSHH
     LEEFIRVWAE YDPAATGRIH HTDMYEMLRK LEPPVGFGKK CPYRFAYRKL IRMNMPVDDS
     GCVRFTTTLF ALIRESLNIK MGPASVMDIK DAELRDTIKE MWPLQAKKML NLLVPNDEEL
     TCGKMTTGKI YAGLLIYETW LANGKLSKIE APVIEGNCKK SDDSNSTSPI RSTLITPQPA
     SVNAEYERRH FNFDDVEQYV HLEARPTVTE VSTNSQVPIG SSHSPPTCDL RPPAPKGLAP
     PTSGTNETSP AGSSLPPSPF LDFASAVTSL MQQVNLMVER ERTQKFLGRL SDEVDWESIV
     AYRAQQGLRN RSRSRFLAAA TANIATRNLA KTAHRPSYRY FGGNQHNQLT NNPITGSAPT
     FAVDEVVSNG VAEHREPQHE MVQHPPPHPQ RLVKPVSQWV HSSALNLARE DWYNRWNHAN
     EWNEQSPSPI AHDFGLHMCS PSYREKSNSP IESPLSTRYF SRTRNINFPP LMPSPTAELN
     QAELHVSGGQ YRNRPQAMRP NGVDYRVSMC HSVNESASLQ WPPDIGQRKR QCQRPQHFF
//
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