ID A0A068Y6X6_ECHMU Unreviewed; 834 AA.
AC A0A068Y6X6;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Nucleotide excision repair protein {ECO:0000313|EMBL:CUT99350.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CUT99350.1};
RN [1] {ECO:0000313|EMBL:CUT99350.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CUT99350.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; LN902845; CUT99350.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y6X6; -.
DR STRING; 6211.A0A068Y6X6; -.
DR eggNOG; KOG2179; Eukaryota.
DR OMA; GRFANKA; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 488..548
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 550..608
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 615..690
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 18..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..811
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..834
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 93214 MW; E61AEC3D8B264318 CRC64;
MPSLRTRRRV YKSQYFEKLS DSDAAVSSGD EFTPPPKLKS TPRSKTASRR NKSQSKAEPS
NAASPIILDM KGRPLSRSNG KKKDNTEEDL TVTKLFRKFS RRSKKVKVEE APKEVVKVEE
FSTDSEPSDA DGWEDVSNPP SDAEAKQAAS SHKEFEFLSQ LIQKPENGAT KVEDEGPLEI
SVSALPRGRS SCKDPKALAA LALARQIRER ARTLHIFYVL EFLTFGRFAN KACDDAMIRA
LALSLIVIPK SWDLAALQSL VHTFASLNHN GPKIKNPDIR EAIQTRLQVG STSAVDCALL
MVAALRACGL DTRLVLAFAP PSLKPGTNTT ARGLKKLKPL GLSSRNSKII SSESEDEKQR
LSSKYFFFGE VYLPSDEVWY SVDLSSPTGR VMADVSFPFT NFPYVVGFHS THCSYLGRTP
IDLAPRYDPT WMSMSRDHRI PDPLWKKLLA TLRGHCDGDV VDLRAKDVGG MEEMRDAAGM
ERIFDYLRSL PLPVKVQNFK GHPLYALRRH LLKFEVIYPP DAPVVGFLKV GGKASGVTEP
VYPRECVHIC HTRESWLKEA KTIRLGEKPA KEVKAMMTMK RKLLQETNGP TPMVELFGPW
QVEDYVPPVA ENGVVPRNEH GNVELFKPCM LPIGCVHIRL PGIQHTAKRL EIDAAPAMVG
WTFHKAGWAH PEYDGFVVCR EVVPILVDAW REERMSAAVA AAVDRTERAL SNWKRLTRNL
LLWQRIEAGF QLAKATVHAA PLPMSTGEVK KSSSSKPTLS DLPWQSLATA KPVFPRLLDV
SDLVKAVPNA KPKLISKRSA RKPPRRKRRR QRQPSTSEDD EEEDEESFTS LDSD
//
