ID A0A068Y9I0_ECHMU Unreviewed; 364 AA.
AC A0A068Y9I0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Gelsolin {ECO:0000313|EMBL:CDS41196.1};
GN ORFNames=EmuJ_000882300 {ECO:0000313|EMBL:CDS41196.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS41196.1};
RN [1] {ECO:0000313|EMBL:CDS41196.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS41196.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; LN902841; CDS41196.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y9I0; -.
DR STRING; 6211.A0A068Y9I0; -.
DR eggNOG; KOG0443; Eukaryota.
DR OMA; CDNEERL; -.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR Gene3D; 3.40.20.10; Severin; 3.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF85; HP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 172..219
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 41985 MW; 46961FE8EA57A8FA CRC64;
MSLFGRKLSK QDSTTAKENR KSSAMDDPEW KSILEINSEV LKVWRLPDKG PAIPLPEEQV
GFFMNDEKYA ILKTSNHNRK LVYDLHFWIG LTAAQKMSSE PPEKVAQVMA LLNENLVMHR
EVGEFESPRF KSYFKEFGVL SGNVGSLFDP ENPQKYQKRL LRFALTRNKT RIEVTEVPIS
RHSLNSNDVF IFDEGTRMTQ WNGARCDNEE RLAARKYIEK SLKLRKTKCT SEFVDEEDLL
DNNELYAKLG NAAVPPRPMR LLKSKFKKSM YRLSDDSKKL TLSLVYTNKV YRSGINPNDV
SFVDTLHELF IYIGPGANEN ERNSVWTQAD KFLKDSSMPY KSIAVFNAGC YCDGFEEIWD
DAQH
//
