ID A0A068YBA2_ECHMU Unreviewed; 787 AA.
AC A0A068YBA2;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Rho GTPase activating protein 12 {ECO:0000313|EMBL:CDS42070.1};
GN ORFNames=EmuJ_000976700 {ECO:0000313|EMBL:CDS42070.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS42070.1};
RN [1] {ECO:0000313|EMBL:CDS42070.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS42070.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902842; CDS42070.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YBA2; -.
DR STRING; 6211.A0A068YBA2; -.
DR eggNOG; KOG1450; Eukaryota.
DR OMA; PECHYAT; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR23176:SF129; RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 715..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..201
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 498..688
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 88163 MW; 1C296ABBC5330FAE CRC64;
METTDTPKGD DEPISRSLPQ PECSNIESQS ASSSIEQRGS SDKFPAGFRS AFRSSHSLTL
PKKPTQIPPP VPSASVRPDC PSLSSAVSPT PLLMAPPKPP RANAKSMDLK RGKPSESFNA
YDVEDQQQKD DQQRKSASPS QQKNIRMRHP GGWVEKTDDD GNSLYIHPES TDQWVKAVSV
NGETYFYEKT SRRSAWVLPT VEPRNVAIEP ASCRRPTSTI GELFSAPVTC FSPGTINTID
LSEAQAKFGA RKTPVSKSGD NLSTISAQDD GSSRFYRVSK DHITGPIENK IRATERRGQV
NFTKYSANGV SLPKKWIPSI LVLIGPTLYV YKDSKAQQPA AASPDPAKSI GMVSPRGSAK
MSDSGIKFFN FLSKGSCISG KPELESHVKH LQISPTDKTH TTREHTFVLK DFTDSDNVAE
YLIEVSSAEL RKAWETALQY SQDFVKEDRF DRRALSTRPP PNVDQKVVVM LREFFRKRPT
LESIREAGIL QNEPVFGSNL IELCQKEQTK VPTFVTRVIL AVEARGLETS GLYRRSGNGA
VIQKLRNQVN HSEYSLNSDE WDIYELSDSL KLFLRELKEP LLLYSLYSDF RDFSSTMGSD
SVDQNVSKMR RILQKLPECH YATAKLIFEH LSKVAALEST NQMSAKNLAL VFGPNIMWQD
TPTDDYAHFP IVGCACTEFM ITNNAAKRQQ PLTHCNRLSV LVKGTWSATS PSPPLLLPFL
YCVLYCLITI LLHYLLMHLS GYHRFFVITR LRLYFYNDCY KKRNDVSAAS CNNKPLAPSS
RRKRNNL
//
