ID A0A068YGK0_ECHMU Unreviewed; 631 AA.
AC A0A068YGK0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Protein hook 3 {ECO:0000313|EMBL:CDS43699.1};
GN ORFNames=EmuJ_001149400 {ECO:0000313|EMBL:CDS43699.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43699.1};
RN [1] {ECO:0000313|EMBL:CDS43699.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS43699.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR EMBL; LN902848; CDS43699.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YGK0; -.
DR STRING; 6211.A0A068YGK0; -.
DR eggNOG; ENOG502QQM8; Eukaryota.
DR OMA; RGQLDTY; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR CDD; cd22222; HkD_Hook; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF39; PROTEIN HOOK; 1.
DR Pfam; PF05622; HOOK; 2.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701}.
FT DOMAIN 6..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT COILED 180..417
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 473..541
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 631 AA; 71518 MW; B224386BC9B55B31 CRC64;
MALELPERLD YLLSWVKEFE FVDQGLRFED LCDGVIISKI LVSVSPCSFS ASWYSRIRSG
GGISSVHKCF NLNHIVGAIS QFFENVIGQN LAIFQLPNVS LIAEKNDVGE LLRLLQLVIC
CAVNGENKEK YIQAILIMER AVQQAIMESV QEVMNETSSK GDELSLMSKS DRDDAFAHKC
HELEAKISQL EAEKATAEAE LEDALRKIAL LEEHSGDSGG IGDGSETVGS VAATLQLRQL
QEKLHNVQVE LFQAEADSQE AKLRLSEALV TIEDLRKMNE ALTLEVSRTA HFKDELDIAR
EEMQAANRQV ASLEQWKKRR AEEMVALRVR CSKLEEDNAA CLKVLDELKQ ANRLNSSLRA
NAEASRNQSV EANSRVSELE LRTMQLEEEL KQARADLQGS LRENQTLLEE MRRLREHHEK
AFTSTDLEAG DRLSQLQSSL NLPSKPVESN ESGDQEITSD AVYEIEQRYR GYLAKALEVI
RQLNRRVVAA ETAAVNQNCE QKPDSEVSRL QALLAEKESI IEQLERHYEQ ARRQRDLEDR
MVLTAWYHLG MRVNRAHTER LLHEEASSGA SSSFAAFQSW SYASHWTIPL ILDFYGRLLP
FFPLCIFVYR ISPGLILFEL TFYLFAHPLI C
//
