ID A0A068YGW6_ECHMU Unreviewed; 1065 AA.
AC A0A068YGW6;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Small conductance calcium activated potassium {ECO:0000313|EMBL:CDS42562.2};
GN ORFNames=EmuJ_001027800 {ECO:0000313|EMBL:CDS42562.2};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS42562.2};
RN [1] {ECO:0000313|EMBL:CDS42562.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS42562.2}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LN902842; CDS42562.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YGW6; -.
DR STRING; 6211.A0A068YGW6; -.
DR eggNOG; KOG3684; Eukaryota.
DR OMA; SEMRIQH; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR043787; DUF5729.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR10153:SF33; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF19000; DUF5729; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01451; SKCHANNEL.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 504..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 821..897
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
FT COILED 902..929
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1065 AA; 118744 MW; F7BFF4DD8442EC8F CRC64;
MNTSDIEKLQ LAPKKPQLSL LDNDCRLTRI NEVEGNEVNP TPFIHSIKPL EELSLGDVGE
TPSESYQIAH LPSWPATAGV GARTKHLERV STIASGCASF KESLSISPLH VSRKTSDVNI
DDAVRRSPRS RSDNNIAAAY TLSPIIIQTS YLTNENSTEL FHPMEGQRPM TSLGVNIKDR
GFSASVDDLH DTNFCFTLEN PHKDDLNNLA KTTTSSMNAQ KKQFIFRAVS ESTEDGHASD
AEAAAIKRLA EQTPFFGGVR SRCNYCCAMG ETAAQLPTHT FRGRCACHES ICSCHKQHAV
SVVNLPSLRR SRRTPGLDEI SYDFMRASGA ISGFSQLRSV KGIKHDREKQ EMCSAFPPAI
VANLDTRGAV ALLAASTRPR LIANMRKKTN KAHSSQEEVP TSLKPITWAS SFDSSCNIQS
QDDDYSRSGP PKWEELACVP MTGKQPALIN RNSNYGGSIA QETLLGIKNC KMSAAMERHQ
SNSTFHNVGY RLGRRRRMFQ QRSVVSDYSL VFAVLGILLM IVENELTSGQ VVTKDSIWSL
MLKSLITCST LALIGLVVFY HIIVVRILSF DDCIEDWQIA WDRSRVAKLV MEILVCAIHP
VPGNFTFSWP SSYYLFGSNI LLSCAHCKNG TLDPSLLTSG AFVPRVSAIS GSPHVIFPSN
KVVSIDIILS LPMFLRLYLI FRVVVLHSKL FTDTGSRSIG AMNKVDFTTQ FVFKTFMTIC
PGTVLVAFIL GFWAVLAWML RACERVQDPV FGNLFNSMWL VAVTFLSIGY GDVVANTYCG
RAISIVAGVL GSLCTALVVA VFAKRLELSR AEKHVIHFMM ESTLTKQMKY YAANVLRETW
LIYKYTKLVK KLNASTIRKH QRKFLRAIHG LRHVKLEQRK LQDNANTLID LAKTQSIIND
TVSEMRIQHT RLQIRLEAIE ESLVRIQEQF TTLPIILKHI RMQTRNSSCS NQKSEDRMDL
EECCTNQSTT NPYMCYRQTS SRIFNQQGSR ATTIRCDDSD LVIHNSAAQL LTNDRLEAAA
QSAVSFESTQ SHKPPSYARD CLDVEPVQRA ISEPPTSFLA AVRQP
//
