ID A0A068YHD4_ECHMU Unreviewed; 1587 AA.
AC A0A068YHD4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Zinc finger protein {ECO:0000313|EMBL:CDS42727.1};
GN ORFNames=EmuJ_001044300 {ECO:0000313|EMBL:CDS42727.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS42727.1};
RN [1] {ECO:0000313|EMBL:CDS42727.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS42727.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00475}.
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DR EMBL; LN902842; CDS42727.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YHD4; -.
DR eggNOG; KOG1245; Eukaryota.
DR OMA; TEFIACY; -.
DR GO; GO:0090535; C:WICH complex; IEA:InterPro.
DR GO; GO:0140801; F:histone H2AXY142 kinase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15489; PHD_SF; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR047174; BAZ1B.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR013136; WSTF_Acf1_Cbp146.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46802; TYROSINE-PROTEIN KINASE BAZ1B; 1.
DR PANTHER; PTHR46802:SF1; TYROSINE-PROTEIN KINASE BAZ1B; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF10537; WAC_Acf1_DNA_bd; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51136; WAC; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00475}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 27..135
FT /note="WAC"
FT /evidence="ECO:0000259|PROSITE:PS51136"
FT DOMAIN 1173..1223
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1320..1372
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1485..1558
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 298..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 753..795
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 337..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1444
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1587 AA; 177572 MW; A13A1EBF8F2065B1 CRC64;
MPLLGNRLHV LNTVVKKPRK SSEFTPMFKF VVPDTKEICS SEDELRRKTT LYKSKIWTCR
VTGRANLTYK EAIKSEHVSL NLLKKSISDH YRATILQIVH KSTSPLEPLT QACWAKVHER
FAVGEPVLLK VDSNKPIRAT ILGIDEAIDR PVVIDLSKDE TSSPNNSDKE NNVNTKRSTV
TQVRFLHLCI AILRVHRAPS KDHIRMFIRA HAMRYGPSSS GPWVVDPIAL RKYCPTLKMS
NNLVDKDKLR MVSETYEMKF YGKITSEKHK GHDASGETAI KLSPKNLRVF KNLSALRNDS
PRSPVEAVPL NPKETPDGKL SKKMKQAILS FEKSMGSPPS ARKSKSDTSL KSDVTLPPIA
KRLIRSLKGS VEANALKVIV SRCVSLLTDA QIRALPDAAQ KLVIDKKVAI ENRKKMQNMT
PEQQKAYLRD LRLQRRTLID ENAPFLETGV QIAQLPEPRA FPLPPNMTSL QFSRILSFTE
FIACYQPLLT ESALSPGEML YPTRIKQLAT DLCPPMTDNE KEEEFTTDVE EESALTSTDA
GLPRASVQGL RCLSLDRVLR AVSEQHMSAA AYRCLARPMG SLLRLLFFSE QFSKQTELGI
QLSKIPITPY TAPELLRLLL QCELANDTCS TNDRAVARIY QIVPNSSGMR NLLPSRDALG
AASLIKHLTS ADLFALDTEH RILAIEVLIE LMLDFDTMDE YMHMCNRRAI KAWQDRLALA
KQKRTVVPPA LSAAKSTVEK EPESDDLASI VKSRRVLAAK AAEEREIREA KERKRRELEA
KIDAEEKALA KAEYEHTIAS TEAKLAFRVG ALGTDRRDRR YWRFFCAPNR LFVESNWAPE
EYHVGDSLIK EPSAVTSFPP SHTFPEGLGS YEIVHRFGYA ARSQWYVFDR PDELDALANA
LVERGARESQ LRKNLVQSGL LDSVKELITL SKVEESHNES DEGRSVSYLS PDEVVISTIT
AKERSDAESI LANVLLKNVY ETEIHLRDGG LGGVPDFSAW MTNILAIQAK YGLCLSLTGS
VPSTPAKGNP GAVPPPSTIP TTSFASKTPL RSVAEALIAV GQHVHRRFLS VPKLRLQQTA
RRRGENGVDG VIYENGEQAP EEDGCKAIGE EEGGQGQRSE TIESEKNRAH EGDVELWMDA
WVKAVRSAAT LSRLNVLHAC LDACILWEKS VANIRCRICR RNKDDDSLLL CDGCNSGFHL
YCLRPPLHSI PSGDWFCVSC KPPSCSGATS QQRRDRREAS EGSDSDEARS SASDSGDESS
SSGREEEDVC LRRGQQRSPR SRLRRRPSTG QPISRSSSRS SQPSKALSKS PSSLNPVSND
TICLVCDDGR MEEDELVGCS TCPNAFHPNC HNPPLRSANR RAPWMCSVCR IGRSVSGGLS
AMGQSLRLRA SSRVNRKSSY LRLHRVQTTP KKRPRPISDD DDSSDKESDD DSREEDEEEV
EKEERANDTE TTEEQADERA VFAPPAKRLR IAPQFTCADL ITAVRRHRSS WPFQEPVDPK
EVPDYYEIVV DPIDLSMINS WLENGRYEGA EGPRFLSEDL AKMFFNAELY NSADSDIWKA
GSHLENYVQS LFKKFAPPVS YKREKLN
//
