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Database: UniProt
Entry: A0A068YKD2_ECHMU
LinkDB: A0A068YKD2_ECHMU
Original site: A0A068YKD2_ECHMU 
ID   A0A068YKD2_ECHMU        Unreviewed;      2008 AA.
AC   A0A068YKD2;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   SubName: Full=Sodium leak channel non selective protein {ECO:0000313|EMBL:CDS42625.1};
GN   ORFNames=EmuJ_001034100 {ECO:0000313|EMBL:CDS42625.1};
OS   Echinococcus multilocularis (Fox tapeworm).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Taeniidae; Echinococcus.
OX   NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS42625.1, ECO:0000313|Proteomes:UP000017246};
RN   [1] {ECO:0000313|EMBL:CDS42625.1, ECO:0000313|Proteomes:UP000017246}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Java {ECO:0000313|Proteomes:UP000017246};
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A.,
RA   Sanchez-Flores A., Brooks K.L., Tracey A., Bobes R.J., Fragoso G.,
RA   Sciutto E., Aslett M., Beasley H., Bennett H.M., Cai J., Camicia F.,
RA   Clark R., Cucher M., De Silva N., Day T.A., Deplazes P., Estrada K.,
RA   Fernandez C., Holland P.W., Hou J., Hu S., Huckvale T., Hung S.S.,
RA   Kamenetzky L., Keane J.A., Kiss F., Koziol U., Lambert O., Liu K.,
RA   Luo X., Luo Y., Macchiaroli N., Nichol S., Paps J., Parkinson J.,
RA   Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M., Salinas G.,
RA   Wasmuth J.D., Zamanian M., Zheng Y., Taenia solium Genome Consortium,
RA   Cai X., Olson P.D., Laclette J.P., Brehm K., Berriman M.;
RT   "The genomes of four tapeworm species reveal adaptations to
RT   parasitism.";
RL   Nature 496:57-63(2013).
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DR   EMBL; LN902842; CDS42625.1; -; Genomic_DNA.
DR   GeneDB; EmuJ_001034100.1:pep; -.
DR   Proteomes; UP000017246; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 2.
DR   Pfam; PF00520; Ion_trans; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000017246};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017246};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     20     40       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    101    123       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    344    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    471    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    853    876       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    928    945       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    987   1008       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1104   1127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1200   1217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1237   1262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1269   1287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1302   1322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1334   1356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1421   1443       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       13    254       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      308    415       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      428    499       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      859   1132       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1197   1453       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   2008 AA;  225141 MW;  EE7898F3D4F3D897 CRC64;
     MGVNVESSSR RNRAYFQQSW NCFDAFMVFC LWASIVLQCF ELRATWRTGK EEQKFWRQYG
     WLSVVRCPRP LILIRVFRAV LKLQLPPARV NAIFQRSTHQ IYNVSVFLLF FMSLYGLLGV
     QFFGDELNYH CVAKSANESN LLKSDLAIPD SYCNPFAPET DNQCPKNMKC VRARTSIADE
     GSYASFEAFH ISMFTVYQAS SQEGWVFIMY RAMDCLAPWK GVVYFITMIF MLAWLVKNVF
     IAVLTETFAE IRVQFQQMWS PRIATDTDFS KIFQFDGTSW KLVPVHERKS RGLAPRFVEE
     TLLKSTGFNI VIMLLVLANA ITAAGQHFNH QRAFDGQIHM DGFYFAELGF TMVFNLEAAF
     KIWCLGWRTY WSRSLFKFEL MLCIGTTLHC IPQLYRTELT YLAVMRIVRL IKASPMLEDF
     CFKAFDEEFD RFETFPKAFM SMFQILTQKG WVAVMHDTMD VVDSAAVTTG VAIYFVFYHL
     FVTLIVLSLF VAVILDNLEL DEDIKKLKQL KMREISAETQ QKLPLRLRIF EKFPNRPQMI
     RDSFMRQFAA VSALEEVEEE AVSEILAAAT TMASISASAA LIPSGLASAS GTVGAAGAGG
     GGGGCGGGTG PGAKPVPQSH SVPGTSGAGD SGTPILVAGG WRSKAAETAA AISCSREIRR
     KVHGLHGEEK VRAIVYLLNE SNKTRMLSMD QPPNANGRSL LSTQHHIRLE RRSLRNRSGG
     LLGTAFLGRD GTAMGMSVGM GSGAGSGGGA AGGLSAVSGL GGSDSAADSH AGLDNTGHYD
     IKVLQQKAQM AEIKRTQQEE ELRENHPLFD RPLFTLGRQS RLRRFCSLVV RARHKASRSS
     SGNDSNGGSI HKILGFVTYL DWTMLTITIL SCISMSLETP HRRLMNAPEL KIGEYIFFVG
     MTIELALKIL ADGFIFTPNA LLRDFGGFLD IFTYIVSLTF VSYFMRVEKL GPGSVGQLFM
     VLRCLRPLRI FCLVPQMRRV VYELVRGFRE ILMVTVLLVV FIFIFAVYGV HMFGGRLAIC
     NDRTITRKED CKGVFHRELS VTRMKSFKGS APKFLVPRVW ANPRNFNFDN IGNAILALFE
     VLSLEGWVEI RDVIKARIGP THVVYIHLFV FVGCLIGLTL FVGVVIANYS ENKGTALLTV
     DQRRWLDLKG RIKLTQPLHI PPRPKLRPEP GQMPISSETT FLRFRCLIYD ITQHIAFKRA
     FALLVLFNSA LLFFPFNERG AEANPWVKIR YRVQVTLAMI FTFLFCVECV MKIIALTFNG
     YWQSKRNRFD MFVSTLGLIW IVLHFSLRST PANRIISNNS GWAIQMLRFF TIAGKYVTLK
     MLMLTVTMSI YKSLFILTSM VVLMLVYGLM GVVLFGSVKF GDNLGRHANF HNAFRAIILL
     SRIVTGEDWN KIMHDCMIQP PFCIVKETFW ETNCGNAQAS LAYFCSFYVI ITYVMLNVLV
     AIIMENFSLF YSNDEDAIMS YNDIRNFQQA WNIIDVNRKG MVKSYYVRFL LRLIPRERVG
     FDLSKKRDKQ LFKEMCYEVE TLRGGRDKEV SFHDVLMVLA YRTVDITKTL QLEELIARED
     LEYAIEEEVA RQTIATWIER CIFRKRQKHG HLHFSMHSGS DRPTSGQSFD DTNKETSTPK
     ADFAKSSIRT RPSKIKFSRD ELNTRTESVD IPPSASTTNQ SPPTTPTLQP ILSPVATTIR
     ATDTAVARMA GFQDTCEARG RVNGRLDTKP LKSDSHLPDG LLSNSISNKA GGSSLLPPPA
     SPASPSLTFV DSCTKSKQAS SNTSSMNPPE TELHKGFRLS GSSGNFLRRR SMRASKTHTS
     LFSGVVEDSD QLPRLSLFSG SGMPAIQEAG TGQIKNPSIE LIELNTTSPS LSIPTGDKQF
     LDSGASSLSE QAGEILEKSG QNESTQISPS CEKRSAVKSL TDEHPEMTAF TQNVQTSCQD
     VKSWWMQQIH PDLPPATTTS ANDSLEKIAG GAWDGSLESF LPSVVVTSRQ PLASRIRQRA
     HYEGSINERQ ESISFGGGKR RFLNDPVA
//
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