ID A0A068YN75_ECHMU Unreviewed; 607 AA.
AC A0A068YN75;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Leucine aminopeptidase protein {ECO:0000313|EMBL:CDS43570.1};
GN ORFNames=EmuJ_001133600 {ECO:0000313|EMBL:CDS43570.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43570.1};
RN [1] {ECO:0000313|EMBL:CDS43570.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS43570.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; LN902848; CDS43570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YN75; -.
DR SMR; A0A068YN75; -.
DR STRING; 6211.A0A068YN75; -.
DR eggNOG; KOG2597; Eukaryota.
DR OMA; HDKTWIE; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR000819; Peptidase_M17_C.
DR PANTHER; PTHR11963:SF52; CYTOSOL AMINOPEPTIDASE; 1.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF00883; Peptidase_M17; 2.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 2.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000313|EMBL:CDS43570.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 400..407
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 607 AA; 65803 MW; 4A5FD342AC550530 CRC64;
MLSIMRGGLG LLAPASLGRI YASKRHFSEE SSEYQRERKL AGLVGGYAVQ RHNQGLLSPA
IAYVDEVFLN GGIKDRISKC CLSKIGAMDL CNATFLQSQY CIVCNPLIIR SAQNKECDFK
DDPGQGPSSW RRIYHDKLQM CIGRGVQTLQ RQGVSEIFVD PFTDAEMAAE TAHLAAYSFD
ELKNPKSRVN QPPISCFTAH FDNDPDGFQT RRKLLAAWNR GRILAQAQNQ ARRWMEMPAN
LFPPEVFAHE IEEALSEASK SAAGDASLTV EIHDKTWIEQ QDMGGVLGVA RGSTRPPCFV
EINFVGDPSR LNDHIALVGK GVTFDAGGIS IKPSAGMGDM RADMGGAAVI TSVITGLIQL
QTPINIRAYL PLVENMPDGN AIRPGDVIRM ASGTTVQVDN TDAEGRLILA DALHYAQSRN
PLFLLDAATL TGAISVSLGD QYTGLFCNRI VQQRNISNIW PPGVVGVSDE TSVASGTATE
TSSVKIPTII GSLNHCGLVK NDPFWHMPSL YFKQLKESSI NADIANITGG AFAQLGGSGA
ASAFLQSFVS PRIPFVHLDI AGVMKTVGDD PGMRRGMTGR PTRPLIHFFD RLARYGSIKA
SDEDEDV
//
