GenomeNet

Database: UniProt
Entry: A0A068YUX3_9BURK
LinkDB: A0A068YUX3_9BURK
Original site: A0A068YUX3_9BURK 
ID   A0A068YUX3_9BURK        Unreviewed;       300 AA.
AC   A0A068YUX3;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:CDS52250.1};
DE            EC=1.1.1.60 {ECO:0000313|EMBL:CDS52250.1};
OS   Polaromonas sp. CG9_12.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas.
OX   NCBI_TaxID=1504672 {ECO:0000313|EMBL:CDS52250.1, ECO:0000313|Proteomes:UP000043372};
RN   [1] {ECO:0000313|EMBL:CDS52250.1, ECO:0000313|Proteomes:UP000043372}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Smith H.J., Foreman C.M., Ramaraj T.;
RT   "Draft Genome Sequence of a Metabolically Diverse Antarctic Supraglacial
RT   Stream Organism, Polaromonas sp. Strain CG9_12, Determined Using Pacific
RT   Biosciences Single-Molecule Real-Time Sequencing Technology.";
RL   Genome Announc. 2:1-2(2014).
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CCJP01000005; CDS52250.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A068YUX3; -.
DR   STRING; 1504672.gene:199031691; -.
DR   eggNOG; COG2084; Bacteria.
DR   OrthoDB; 9777604at2; -.
DR   Proteomes; UP000043372; Unassembled WGS sequence.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000313|EMBL:CDS52250.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000043372}.
FT   DOMAIN          16..174
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          179..298
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        185
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   300 AA;  31229 MW;  529D3C33414BBF5E CRC64;
     MTTLLTKNYE SSISCKVAFL GLGVMGYPMA GHLALAGHDV TVYNRSPGKA QGWCSEFKGA
     SASTPREAAD GADMVFCCVG NDDDLRSVTL GANGAFAGMK PDTIFVDHTT ASATVARALY
     SAAKAAGLQF IDAPVSGGQA GAENGALTVM CGGDAAAFDA VKPAGMAFSK AFTLMGESGA
     GQLTKMVNQI CIAGLVQGLS EAVAFGQKAG LDVNQVLDVI GKGAAQSWQL DNRGKTMVAD
     RFDFGFAVDW MRKDLGLVLD EAKRNGARLP VTALVDQFYA DVQAMGGQRW DTSSLVKRLK
//
DBGET integrated database retrieval system