ID A0A069DHI4_9BACL Unreviewed; 870 AA.
AC A0A069DHI4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN ORFNames=TCA2_2363 {ECO:0000313|EMBL:GAK39874.1};
OS Paenibacillus sp. TCA20.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1499968 {ECO:0000313|EMBL:GAK39874.1, ECO:0000313|Proteomes:UP000028160};
RN [1] {ECO:0000313|EMBL:GAK39874.1, ECO:0000313|Proteomes:UP000028160}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TCA20 {ECO:0000313|EMBL:GAK39874.1,
RC ECO:0000313|Proteomes:UP000028160};
RA Fujinami S., Takeda-Yano K., Onodera T., Satoh K., Sano M., Takahashi Y.,
RA Narumi I., Ito M.;
RT "Draft Genome Sequence of Calcium-Dependent Paenibacillus sp. Strain TCA20,
RT Isolated from a Hot Spring Containing a High Concentration of Calcium
RT Ions.";
RL Genome Announc. 2:e00866-14(2014).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAK39874.1}.
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DR EMBL; BBIW01000003; GAK39874.1; -; Genomic_DNA.
DR RefSeq; WP_047911019.1; NZ_BBIW01000003.1.
DR AlphaFoldDB; A0A069DHI4; -.
DR eggNOG; COG1012; Bacteria.
DR eggNOG; COG1454; Bacteria.
DR OrthoDB; 9815791at2; -.
DR Proteomes; UP000028160; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000028160}.
FT DOMAIN 14..410
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 464..850
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 870 AA; 95502 MW; 666997881591AAB9 CRC64;
MAVKNEAVSK EVTAAEYINE LVTKGKKALE AFMQLDQEAV DRIVQAMALA GLDKHMNLAK
LAVTETGRGI YEDKIIKNIF ATEYVYNNIK YDKTVGVIED NEFENYQKIA EPVGVIMGIT
PVTNPTSTTM FKALIAIKTR NPIIFGFHPS AQNSSREAAR ILRDAAIKEG APADCIQWID
APSMEKTNEL MNHPDVALIL ATGGGAMVKA AYSCGKPALG VGPGNVPCFI EKTANLNQAV
TDLILSKSFD NGMICASEQA VIVEEPVYDE VKKRMVADGC YFVTKDEAAK LTTYAISADK
CAVNPKIVGQ SAVDIAKMSG IVVPENTKIL VAELDGVGEK FPLSAEKLSP ILACYKVKTV
EQGIERAAEI VSFGGMGHSS VIHSNDDEVI SRFADHLKTC RILVNSPSTH GAIGDIYNTN
LPSLTLGCGS YGRNSTSSNV TAVNLINVKR VARRTVNMQW FKVPSKVYFE KGATQYLAKM
PDISRVLIVT DSMMVKLGYV DKVEHYLRQR RKPVFIEVFS DVEPDPSTTT VENGTKLMNS
FEPDCIIALG GGSPMDAAKA MWLFYEHPDA EFDHMKQKFM DIRKRIYKYP KLGQKAKFVA
IPTTSGTGSE VTSFAVITDK NKGNTKYPLA DYELTPDVAI VDPDFVYSLP RVAVADTGMD
VLTHAIEAYV SVMANDYTDG LAIKAIQLVF EYLEASALTG DKLAREKMHN ASTIAGMAFA
NAFLGINHSL AHKWGGQYHT AHGRTNAILM PHVIRYNAKK PTKFASFPKY DHFTADLRYA
EIARILGLPA NTTEEGVNSL IQAIRDLNKK LGIPASFQEL GFDPKDFEAR VDYLADRAFE
DQCTTANPKL PLVSELADVY RNAFYGRFDK
//
