ID   A0A072P7X1_9EURO        Unreviewed;       728 AA.
AC   A0A072P7X1;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Acetoacetate-CoA ligase {ECO:0000313|EMBL:KEF55797.1};
GN   ORFNames=A1O9_08548 {ECO:0000313|EMBL:KEF55797.1};
OS   Exophiala aquamarina CBS 119918.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF55797.1, ECO:0000313|Proteomes:UP000027920};
RN   [1] {ECO:0000313|EMBL:KEF55797.1, ECO:0000313|Proteomes:UP000027920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF55797.1,
RC   ECO:0000313|Proteomes:UP000027920};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KEF55797.1}.
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DR   EMBL; AMGV01000007; KEF55797.1; -; Genomic_DNA.
DR   RefSeq; XP_013258387.1; XM_013402933.1.
DR   AlphaFoldDB; A0A072P7X1; -.
DR   STRING; 1182545.A0A072P7X1; -.
DR   GeneID; 25283460; -.
DR   VEuPathDB; FungiDB:A1O9_08548; -.
DR   HOGENOM; CLU_000022_3_3_1; -.
DR   OrthoDB; 45466at2759; -.
DR   Proteomes; UP000027920; Unassembled WGS sequence.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR005914; Acac_CoA_synth.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR   PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KEF55797.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027920}.
FT   DOMAIN          79..136
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          153..468
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   REGION          19..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   728 AA;  80085 MW;  3465007A03933356 CRC64;
     MSQDFPDFPK YRSAHMTNHM MNGVDTGNGT NGTSNGVNGV NGHGHDSAEL WRHPRPESTE
     FYAFQQHLMK KYPIRSESYT DLWKWSVDNP AAFWENVWHY TGITAHKQYD SVLDLSAPMF
     PKPAFFPGCE LNFAENLLFP SSNPSAGSLA IIAATETTRE QVTWAGLRER VRMCAAAMTA
     HGLKKGDRVA GYLSNHANAV IAMLAATSLG ALWSGVSPDT GVHAVLDRLK QIEPVLLFAD
     NAVTYNGKTH ETHAKISQVI AELSCVKNLI IFETIQAHKF DLSTLEARKE TTVETYDSFA
     SKGDSLRPLR FTYLPPDHPV YILYSSGTTG VPKPIVHDAL GTLLQHKKEH LIQSDIKPGE
     KLFYFTTTTW MMWHWLVSGL ANGATIVVYD GSPFQPHKEM SMPLLVDELG INHFGTSAKY
     LSVLEQAKIF PRGASPRSAT LQSLKSIFST GSPLAPSTFH YVYKALSPPP PHQGILLASI
     TGGTDIISLF GCGSPILPVH AGEIQCPGLG MAIRSFSTDG TDISQTGEAG ELVCNVPFPC
     QPCMFWPPGS SGEKRYKSSY FEVFKDQGSG KPIWHHGDFV RFNPATGGLW MLGRSDGVLN
     PMGVRFGSSE IYNILLKHFS SEVEDALCIG RKRAQDPDEV VVLFLKMAPG QSFGEDLITR
     IQNMVRKELS ARHVPKIIDE CPVIPVTTNG KKVEGAVKQI LSGLNIKISA SVANSDCLEW
     YREWAATH
//