ID A0A072TFP8_MEDTR Unreviewed; 1396 AA.
AC A0A072TFP8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:KEH16207.1};
GN Name=25480794 {ECO:0000313|EnsemblPlants:KEH16207};
GN ORFNames=MTR_0277s0020 {ECO:0000313|EMBL:KEH16207.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH16207.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH16207.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH16207.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH16207,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH16207.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH16207.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH16207,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH16207}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH16207};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; KL403002; KEH16207.1; -; Genomic_DNA.
DR RefSeq; XP_013442182.1; XM_013586728.1.
DR STRING; 3880.A0A072TFP8; -.
DR EnsemblPlants; KEH16207; KEH16207; MTR_0277s0020.
DR Gramene; KEH16207; KEH16207; MTR_0277s0020.
DR Proteomes; UP000002051; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF219; ARCHAEAL ATPASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 16..185
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1292..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1396 AA; 159435 MW; 400B54F33630168A CRC64;
MAMQLPSSSS SFSSAFTYQV FLSFRGTDTR HGFTGNLYKA LTDKGIKTFI DDNDLQRGDE
ITPSLLKAIE ESRIFIPVFS INYATSKFCL DELVHIIHCY KTKGRLVLPV FFGVDPTNVR
HHTGRYGEAL AGHEKRFQND KNNMERLHQW KLALTQAANL SGYHSSHGYE YKFIGDIVKY
ISNKISRQPL HVANYPVGLQ SRVQHVKSLL DEGSDDGVHM VGLYGTGGLG KSTLGKAIYN
FISDQFECSC FLENVRENSA SNKLKHLQEE LLLKTLQQKT KLGSVSEGIP YIKERLHTKK
TLLILDDVDD MKQLHALAGG PDWFGRGSRV IITTRDKHLL RSHGIKSTHE VKGLYGTEAL
ELLRWMAFKN NKVPSSYEDV LNRAVSYASG LPLVLEIVGS NLFGKTIEEW KGTLDGYEKI
PNKKIHEILK VSYDALEEEQ QSVFLDIACC FKGCGWKEFE YILRAHYGHR ITHHLVVLAE
KSLVKITHPH YGSIYELTLH DLIKDMGKEV VRQESPKEPG ERSRLWCEDD IVNVLKENTG
TSKIEMIYMN FPSEEFVIDK KGKAFKKMTR LKTLIIENGH FSKGLKYLPS SLRVLKLHGC
LSESLLSCSL SKASEITSFS YCIYLLIYND FCFHQQRRNH YDILTLDKCE YLTHIPDVSG
LQNLEKFSFA YCRKLITIHN SIGHLNKLER LNAFDCSKLE SFPPLGLASL NELNLSHCGS
LKSFPKLLCK MTNIKKIWLQ NTSIRELPSS FQNLSELHEL TVREAGMLRF PKQNDQMYSI
VFSKVTKLEL YNCKLSDECL PIFLKWCVYV TYLDLSWNNF KLIPECLSEC YLLSSLRLDN
CKSLEEIRGI PPNLARLSAI GCKSLSSSSR KMLLSQKLNE AGCNICFPNF SDGIPDWFEH
QSRGDTISFW FRKKIPSNIS IILFPGCMSI PQLYLFVNGY KCFPFSYLIW GFGSIEILES
EHSFLFNLKL EEEITHLSRM SEMDKALLKT EWIHVELNFI KSVWNKSICD RVTEKLSSAQ
MGIHVSKEKS NAEENVIFTD PYREYRNTSL SQFEPPLKKQ RLVEVVVSET EIWQQQHLSL
ESGMQNLVLT ETKEAPLLDR FLRPGYFSNA KNLFSLPKNV SKILNVTIHS DSAVNLTIPG
FPFLFYMVSN INFNDYICQF RWIAAQTDRY RNGELYRCIA DTKGAFVQPA LYEAFGLTVI
EAMNCGLPTF ATNQGGPAEI IVEGVSVSKA GLQRINECYT WKIYANKVLN MGSIYGFWRK
LNKEQKLAKE RYIQMFYNLQ FRNFARKVPI PKEVSQESQP MSTTPTKKAE AKAEATSKGH
DAAQEKAEVP QTYLATLPPK IESQPTSSGE SSSKELAAKQ SGDLYSGLRW LLPGIAFMFI
IHYLSKYLEH LFTRDQ
//
