ID A0A072UBW0_MEDTR Unreviewed; 1252 AA.
AC A0A072UBW0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=25498877 {ECO:0000313|EnsemblPlants:KEH23330};
GN OrderedLocusNames=MTR_7g075463 {ECO:0000313|EMBL:KEH23330.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH23330.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH23330.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH23330.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH23330,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH23330.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH23330.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH23330,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH23330}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH23330};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; CM001223; KEH23330.1; -; Genomic_DNA.
DR RefSeq; XP_013449303.1; XM_013593849.1.
DR AlphaFoldDB; A0A072UBW0; -.
DR STRING; 3880.A0A072UBW0; -.
DR PaxDb; 3880-AES79988; -.
DR EnsemblPlants; KEH23330; KEH23330; MTR_7g075463.
DR Gramene; KEH23330; KEH23330; MTR_7g075463.
DR eggNOG; KOG0952; Eukaryota.
DR eggNOG; KOG2505; Eukaryota.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000002051; Chromosome 7.
DR GO; GO:0005694; C:chromosome; IEA:EnsemblPlants.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblPlants.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IEA:EnsemblPlants.
DR GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:KEH23330.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 34..229
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 263..460
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1192..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1252 AA; 141989 MW; 8A61322A761883F3 CRC64;
MDSYSLKSVF DLPQPFQSCF SFRYFNSLQS ECFPTCYHSD VNMVISAPTG SGKTVLFELC
ILRLLSRSIS SEGRFIHVKG SLKTIYIAPS KALVQEKVRD WNQKFGPWGI CCLELTGDNE
SYTPRNINEA DIILTTPEKF DAVSRYGIES GGLSFFSDIA LLLIDEVHLL NDPRGAALEA
IVSRIKIISC NPKMKLNPLA QVRFLALSAT IPNIEDLAKW LLVPDQGIKR FGEEMRPVKL
TTKVFGYAPA KNDFLFEKRL QNYIFDILMQ YSKGKSALIF CSTRKGAQEA AQRLAQIVMN
FGQSNPFIKS REQQDQLREA SMSLSDKQMQ SYILYGVGYH NGGLCHKDRS IVEGLFLKGD
IQVLCTTNTL AHGINLPAHT VVIKSTQHFN KEKSLYMEYD RSTILQMSGR AGRPPFDDTG
MVIIMTRRET VHLYENLLSG CEVVESQLLS CVTEHLLAEI VQLTVSDITK AIEWMKCSYL
YVRMKRNPEN YGIKKGISAD RLEKHVQEIC VQKVNELSQY QMVWVDEDGF LLRPLDPGRL
MTKYYLRFDT MKQIMRTPES CSLEDALRVV CFAEEIAWIQ LRRNEKKILN DINADKDGRL
RFHILGDKGK KKKRIQTREE KIFILANDCL TGDPSVHELS LIQDINSICS NGCRIAKCMK
EYFVYKKNFK GAVNSALLAK SFNQKLWDDS PYLLKQLPGI GMITAKALHS MGVKSFEALA
EADPRKIELV TGRKYPFGNH IKDSLLSLPP KVDVKLTEME SHTHGKSKLV VTLTRISQSG
QSAKRHYADM IIGLEEDNTI FFHEKIRVDQ FSSPYSTTIL VPISQGKQTI KANFIFEEYI
GIDVHQKLFF MKEISSDVIL KRNRKQASFP PPEEIFVIED DDRNLTHIPQ EETSTLSKDK
EESNSIPTFD LLNEMFEEDE CATEVQEDKF KIITEKTVFD HIREKAKNFS LLSSFENIRC
PPVEVLLGRN HACEKWSNHG HEKTSYHGHE VVVLDDDDNK VPGQTDVNFQ ADLRKAEQED
INLSLTLNDH NIAVNSDNIS SVVDTGIFFP EPKARSYENA TEETVFDHIK RKSEDFPQIS
KLDCLETAIK KTEFFSKNHP NSLKAALGMV AETNFSDMVT GSMLTSDMKT ADVENYSSGF
QVGTSVNHKK SEDSCCTDGV VNISKGVSST NSVQSSNFVP FIGFPMSKEK NWSSDSGSFE
QRSKKQRCSP IESKEEKLNS CEIRRQCCSL ETTGQMNQME PSLGFKSVFS FL
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