ID A0A072UIW1_MEDTR Unreviewed; 1571 AA.
AC A0A072UIW1;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:KEH29033.1};
GN OrderedLocusNames=MTR_4g021095 {ECO:0000313|EMBL:KEH29033.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH29033.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH29033.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH29033.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH29033,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH29033.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH29033.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH29033,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH29033}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH29033};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001220; KEH29033.1; -; Genomic_DNA.
DR RefSeq; XP_013454985.1; XM_013599531.1.
DR EnsemblPlants; KEH29033; KEH29033; MTR_4g021095.
DR Gramene; KEH29033; KEH29033; MTR_4g021095.
DR HOGENOM; CLU_001561_8_0_1; -.
DR Proteomes; UP000002051; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017:SF271; NBS-LRR DISEASE RESISTANCE PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF01582; TIR; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1547..1569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 193..332
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 499..616
FT /note="TIR"
FT /evidence="ECO:0000259|SMART:SM00255"
FT DOMAIN 666..803
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 1571 AA; 177829 MW; 5CB8ACEE8296F4E4 CRC64;
MFFINPNPSM SSFTTDSKRK SYIVYFSFCD KDAASFVSHL YTALRSEDGI VVFWVDYEMR
GNGEIPIPIS MLKVIEHCQV AIICSMMVSY PSNGGLKRGM FGGAFHDFVE RISKDEDKFM
GWVAEISKAY KYSGPKYLLV KDLYSEEIQH IKNVVDRVIC VLNKRINLSC AFYTESLKSS
LQDVIQQLKQ SKCPLLLGIW GMTGIGKSAI AEAIYDQISP YFEDKCFLDN VRVVWETNNG
PVSLQAKLLL DVDKATKTKI PTIELGKEIL KERFRHKRVL LVLDDVNKLE QLNALCGSRE
WFGTGSKIII TTRDRHLLKE HGVDHIYRVK ELDNTESLEV LNRGAFSQAT ITPEDFVELC
REVISYSGGL PLALQNLRTI LHGKEARQWM DMLRSLERLS IPFPQLLEAL EKSFHDLSDE
EKHIFLDIAC FFKGMDQNVV LHALNRQIQC ASFQISLLED KSLVAIDKNN KLEIHVLLQA
MARDIIKRES SNMSNQPKMY DVILSFRGDD SRAKFISHLY SSLQNAGIYA FRDAEIQRGD
HISISVESNW MLEKIMEIGR TGGMVVVPVF YEVDPSEVRH QEGQFGKALE DLMSTISIDE
STKSNWKREL NIGGIAGNES DDVKNIVEHV TRLLDRTELF VAEHPVGVES RVETVTKLLN
IENSEDVLLL GIWGMGGMGK TTLAKAIYNQ IGSKFEGRSF LLNIRELWET DTNQVSLQQQ
ILCDVCKTTA FKIHDIESGK NILKERLSQK KVLLVLDDVN ELEQLKALCG SHEWFGLGSR
IIITTRNMRL LRLYEIYQVY AIEEMDESES LKLFSWHAFK QPSPIEDFAK HLTDVISYSG
GLPLALEVLG SYLSDCETTD WHKVLEKLKC IPHDQVQEKL KESPSDPEKR SRLWRREEVF
DILAKDKGTE AVKGLALEFP GKDCLDTKAF KKMNKLRLLR LTGVKLKGDF KYLSRDLKLL
YWHGFPKTYT PAEFQQESLV AVELKYSKLK QLWNKSQILE NLKILNLSHS PDLTETPDFT
YLPNLEKLVL KNCPSLSTVS HSIGSLHKIL LINLTDCTGL RKLPRSNYKL KSLETLILSG
CSMIEKLEED LEQMESLITL IADKTAIKKV PFSVVRLKSI GYISLGGFEG FTRDVFSSLV
RSWMSPSNNV ISLVHTSVSV SSLVNYKDLQ KLRVLYVECG SDLQLTQDIA RFLDVLKTIS
CTMLEASANS IASEISDMYD SPLIDGCLGL VHTSKSKNHL KSLLIQMGTK CQVSNTAEDS
VSQTTKDTEE AWDSFSLPYD NNSEWSTFSC KGCSIIFDIP IIKPLNLKSM RLFIVYYSSS
ENIISEGFQG VLIINYTKRT IQVYKRDTLI SFDDEDWQSI TSNLELGNKV KFMVVFGEGF
HVENTTVSLL YVVASGNDDN HVGVSGGDNE VINQFREVMV NHLQITWPTD GCYTDGVGLV
ELVPHDLDQP AEEVAEEVCA AEVEDGQKQQ VPLPEGQPEL RAAETPETIG LVLGTQILDA
LKEFRADFVR LEQTVTARLN AVEVKLEKLE DVIAQIPHAS SFKSTSMLMF LSMLLFLLLC
CWVVFLSLLG Y
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