ID A0A072UMY9_MEDTR Unreviewed; 1536 AA.
AC A0A072UMY9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=25496990 {ECO:0000313|EnsemblPlants:KEH27225};
GN OrderedLocusNames=MTR_6g088835 {ECO:0000313|EMBL:KEH27225.1};
GN ORFNames=MtrunA17_Chr6g0487171 {ECO:0000313|EMBL:RHN53046.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH27225.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH27225.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH27225.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH27225,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH27225.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH27225.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH27225,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH27225}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH27225};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|Proteomes:UP000265566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5] {ECO:0000313|EMBL:RHN53046.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN53046.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001222; KEH27225.1; -; Genomic_DNA.
DR EMBL; PSQE01000006; RHN53046.1; -; Genomic_DNA.
DR RefSeq; XP_013453197.1; XM_013597743.1.
DR STRING; 3880.A0A072UMY9; -.
DR EnsemblPlants; KEH27225; KEH27225; MTR_6g088835.
DR GeneID; 25496990; -.
DR Gramene; KEH27225; KEH27225; MTR_6g088835.
DR KEGG; mtr:25496990; -.
DR HOGENOM; CLU_001696_0_1_1; -.
DR OrthoDB; 5477296at2759; -.
DR Proteomes; UP000002051; Chromosome 6.
DR Proteomes; UP000265566; Chromosome 6.
DR ExpressionAtlas; A0A072UMY9; differential.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0071561; C:nucleus-vacuole junction; IBA:GO_Central.
DR GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IBA:GO_Central.
DR GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR CDD; cd13980; STKc_Vps15; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RHN53046.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RHN53046.1};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 27..307
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 530..562
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 697..735
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1120..1152
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1503..1536
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 397..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1536 AA; 171892 MW; 64D61FF42FB54012 CRC64;
MGNKIARTTQ VSASEYYLHE LPSTYNLVLK EVLGRGRFFK SIQCKHDEGL VLVKVYFKRG
DSINLSEYER RISTIKEIFS SIDHPHVWPF QFWQETDKAA YLLRQYFFHN LHDRLSTRPF
LSFVEKKWLA FQLLLAVKQS HEKGVCHGDI KCENVLITSS NWLYLADFAS FKPTYIPYDD
PSDFSFFFDT GGRRLCYLAP ERFYENGGEM QVAQDAPLKP SMDLFAVGCV IAELFLEGQP
LFELSQLLAY RRGQHDPSQH LEKIPDIGIR KMIQHMIQLE PESRFSAEMY LKEYAGVVFP
TYFSPFLHDF YRCWSPLHSD MRVLLCQSAF QEILKQMMNK QSSDDAGVTS GELLEEMVAK
ESASFMDSRR KREDIGKGLV HDQYELLGDI NSLLRDAKNN NKSPAGPQQG IGNAQNSTFP
ENLKSLQSPG ELLQTISNAF RGNDHPFLKS ITMKDLNSLM SEYDSQSDTF GTPFLPLPKD
TMRCEGMVLI TSLLCSCIRN VKLPHLRRAA VLLLKASALY IDDEDRLQRV IPYVIAMLSD
TAAIVRCAAL ETLCDILPIV REFPPSDAKI FPEYIFPMLS MLPDDPEESV RICYASNIAK
LALTAYGFLI HSISLSEAGV LDELSLPQKP FTSSTQTPGR MMINSDVQLL QLRKSIAEVV
QELVMGPKQT PNIRRALLQD IGKLCYFFGV RQSNDTLLPI LPAFLNDRDE QLRTVFYEKI
VYVCFFVGQR SVEEYLLPYI EQALSDMTEA VIVRALECLA ILCKNGFFRK RILLQMIERA
FALLCYPSEW VRRSVVSFIA ASSESLGAVD SYVFLAPVIR PFLRRQPVSL ASEKALLSCL
KPPVSRQVFY EVLENSRSSD MLERQRKIWY SSSQSKIWEM DLLKKGIDEL DSLKSWAEKQ
QGSEAQQIVG TGIQQPGLSD NDKAESKFRD MGAFMHNDSN MLGQRDPQFS EKLQFSGFMS
PTFSGANSLT YDKPSEGIPL YSFSVDRRGM GIPPAASDSP LQMNSLGVSS SAMPWVNPLS
KSFNLANSVP SPKLFSGSFS INNGTKQFHR VVHEPDPKEN ETAFLNSTFQ DVGLSSNNKG
TSISLEDATT QADLSGFQSF ARTSIPDSGW RPRGVLVAHL QEHRSAVSDI AVSSDNSFFV
SASDDSTVKI WDSKKLEKDI SFRSKLTYHL EGSHALCVAM LPGSAQVIVG ASDGFIHMFS
VDHISRGLGN VVEKYSGIAD VTKKDTKEGA ILGLLNCPMD NNSIMYSTQN CGIHLWDTRS
NSNSWTLKAT PDEGYALSLA SGPCSNWFVS GSSRGVITLW DLRFLVPVNS WKYSLACPIE
KICLFLPPPN ASLSSTTRPL VFVAAGCNEV SLWNAENASC HQVLRTANYD SDAEMSDMPS
ALAKPSSKPT SQSDPRRNVN RKYRVDELNE PPPRLPGIRT LLPLPGGDLL TGGTDLKIRR
WDHYSPDKSY CICGPNLKGV GNDDFYETKS SFGVQVVQET KRRPLATKLT PKAILAAAAT
DSAGCHRDSI VSVASVKLNQ RLLLSSGRDG AIKVWK
//
