ID A0A072UVI9_MEDTR Unreviewed; 1125 AA.
AC A0A072UVI9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=LRR and NB-ARC domain disease resistance protein {ECO:0000313|EMBL:KEH33098.1};
GN Name=11445508 {ECO:0000313|EnsemblPlants:KEH33098};
GN OrderedLocusNames=MTR_3g023030 {ECO:0000313|EMBL:KEH33098.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH33098.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH33098.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH33098.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH33098,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH33098.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH33098.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH33098,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH33098}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH33098};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001219; KEH33098.1; -; Genomic_DNA.
DR RefSeq; XP_013459045.1; XM_013603591.1.
DR AlphaFoldDB; A0A072UVI9; -.
DR EnsemblPlants; KEH33098; KEH33098; MTR_3g023030.
DR Gramene; KEH33098; KEH33098; MTR_3g023030.
DR Proteomes; UP000002051; Chromosome 3.
DR ExpressionAtlas; A0A072UVI9; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1237; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 16..99
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 179..421
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1125 AA; 128754 MW; 09644EE1DDC77559 CRC64;
MAELVAGAFL QSSFQVIIEK LASVGIRDYF SSNNVDDLVK ELHSALDSIN LVLDEAEIKQ
YQKKYVNVKK WLDELKHVVY EADQLLDEIS TDAMLNKLKA ESEPLTTNLL GLVSALTTNP
FECRLNEQLD KLELLAKKKK ELGLGESPCA SNEGLVSWKP SKRLSSTALM DESTIYGRDD
DKDKLIKFLL AGNDSGNQVP IISIVGLGGM GKTTLAKLVY NDNKIEEHFD LKTWVYVSES
FDVVGLTKAI LKSFNSSADG EDLNLLQHQL QHMLMGKKYL LVLDDIWNGD AECWELLLLP
FNHGSSGSKI IVTTREKEAA YHVLKSTELF DLQQLKTSHC WSLFETHAFQ GMRVCDDPKL
ESIGRKIVDK CGGLPLAIKS LGQLLRKKFS QDEWMQILET DMWRLLDGDN KINPVLRLSY
HNLPSNRKRC FAYCSIFPKG YTFEKDELIK LWMAEGLLKC CRRDKSEEEL VSGEFCKQIK
GAMVEGSLEM TRHIWFSLQL NWVDKSLEPY LVLSSIKGLR SLILQGSYGV SISKNVQRDL
FSGLQFLRML KIRDCGLSEL VDEISNLKLL RYLDLSHTNI TRLPDSICML YNLQTLLLQG
CRKLTELPSN FSKLVNLRHL ELPSIKKMPK HIGNLNNLQA LPYFIVEEQN ESDLKELGKL
NHLHGTIDIK GLGNVIDPAD AATANLKDKK HLEELHLTFN GTREEMDGSK VECNVSVFEA
LQPKSNLKKL TITYYNGSSF PNWLSGFHLS NLVSLKLKDC VLCSHLPMLG QFPSLKEISI
SNCNGIKIIG EEFYNNSTTN VPFRSLEVLK LEHMVNWEEW FCPERFPLLK ELTIRNCPKL
KRALLPQHLP SLQKLQLCVC KQLEVSVPKS DNMIELDIQR CDRILVNELP TNLKRLLLCD
NQYTEFSVDQ NLINILFLEK LRLDFRGCVN CPSLDLRCYN YLERLSIKGW HSSSLPFSLH
LFTKLHYLYL YDCPELESFP MGGLPSNLRE LVIYNCPKLI GSREEWGLFQ LNSLIEFVVS
DEFENVESFP EENLLPPTLE YLNLHNCSKL RIMNKKGFLH LKSLKYLYII NCPSLESLPE
KEDLPNSLYT LRIEECGIIK EKYEKEGGER WHTISHIPNV WIDDI
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