ID A0A072UWY7_MEDTR Unreviewed; 1864 AA.
AC A0A072UWY7;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=NB-ARC domain disease resistance protein {ECO:0000313|EMBL:KEH34339.1};
GN Name=25490940 {ECO:0000313|EnsemblPlants:KEH34339};
GN OrderedLocusNames=MTR_3g464810 {ECO:0000313|EMBL:KEH34339.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH34339.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH34339.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH34339.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH34339,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH34339.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH34339.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH34339,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH34339}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH34339};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM001219; KEH34339.1; -; Genomic_DNA.
DR RefSeq; XP_013460308.1; XM_013604854.1.
DR EnsemblPlants; KEH34339; KEH34339; MTR_3g464810.
DR GeneID; 25490940; -.
DR Gramene; KEH34339; KEH34339; MTR_3g464810.
DR KEGG; mtr:25490940; -.
DR HOGENOM; CLU_002035_0_0_1; -.
DR OrthoDB; 2995530at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR33463:SF105; NB-ARC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33463; NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 163..391
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 1309..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 34..89
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1311..1333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1864 AA; 211039 MW; B1F47DE87C5D8920 CRC64;
MEGCITDVRK TLVEKLLNKA IEKSRYLFCF TCIVKELNEE KNKLEAERAT MRQHFKVATE
KGKDIQSNAE FWEKQADKLI QEKIETKQRY CFGFFPDCIW RYKRGEELAT KTKEIKNLME
KGEKFENIEI TRCLPGAERY SSQYYISFKS RELKYVELLD AIKDDSNYMV GLHGMGGAGK
TTLAKEVGKQ LRTLEHFKYV IDTTVSFNLE IKKIQNDIAG SLGLEWGDIN ESDRPKRLWS
RLTDGDKILV ILDDVWENLN FDDIGLPNSD NHKGCKVLVT TRELRVCEQM GCGKTIQLEL
LTEEEALIMF KMYADLSNIS SKSILGKVHE ITTLCKRLPV AIAIIARSLK GKKSREEWDV
ALNCLKKPVS MGNVEEDLVD VLKCLKFSYD NLKDEKAKRL FLLCSAFPED EEISVELLTR
LGIGVNLFGE GYDKYNDARS QAIAAKNKLL HSCLLLETKK GDVKMHDLVR EVAHWIANEE
ILVVNSFEKN QKSLVDRSKN IKYLFFQGNL MDLYSSGFDG SKLEILIANT SMDDSEDVPT
SLFENMVGLR ILKLSNTHLS LPKSIQLLIN IRSLSVENVC LGDISVLGTL QSLESLELLY
CKIDEFSPEI AMLKKLRLLD LTDCGIISNN PFEVIQRCPS LEELYFCHSF NDFCQEITLP
TLERYFLMDN YDNWNWPKTK GVALKRNHLS EATYKYVMKT SDYLHLIRIQ GWINLMPEIV
PIDEGMNDLI ELCLGEISQL QCLVDTKHIN SQVPIVFSKL VVLKLKRMEA LEELCNGPIS
FDSMNNLEEL YVNECKNLQS LFKCSLNLSN LKTVTLISCS RLVSVFELST SQSLPLLEEL
EIIDCEKLEN IITIEELADG YNDNKSCYSL FPKLKVLYIE RCHQLQFILP ILSAQDLLSL
EFIEICCCHK LKHIFCQHQD VNLPSLKTVK IEDLPNFIDI FPPKASSNSK DGSKPQTQLD
PIKSNTFSMC CYRYKARSTK IPLVFEDQPQ ECSISLESNS YCLDILNSAQ YLEEIKISNV
PKMKSVFIVS SALRMLETFT IEKCDELKQI IIDTGHINST GGNKLANVFP QLKCLFIQNC
LQLEYIFGCP QVASSGDFIK ELSRNEENGQ QMNLSLEDIK LVNLPMMRCL FVGFKYSFVL
KNLKKMKIFR CEKLESVFST SVLRCLPQLV KLEVEECKEL KHIIEDDLES KSFQSSNTCF
PKLETLIVTE CDKLKYVFPV SICKELPELK VMIIREANEL EEIFKSDKKD EIGEISKSDV
EIPNLERIAF VNLPSLCHAQ RVHFQTIKYG FVLRCEKFSL TSETSHDTFH DDSFSIGNNG
GDENPSAETT KDFAAGSEIQ EASEHQLTSP QEGSTSEITE AATVPTITET KNKPPTQVVV
LKQKGIHINA EEGNISANAK KITSSTHFDA VGSSSSQLVT SECKTSSQDD GDSQIEMTSF
SICTSETNDQ GSLNHDSFKK VSLNIEEQLP KEQFPYITFP VLYQFFPVPC EEELFRGHNA
GDENPSAETT KDFAAGSEDQ EASEHKLTCP QELMTEQLMD RQCLMNQQQT LAETDITIKP
SQEENLEGPT SEITAAATVA TITHEVVPKQ KGIEINVEEG NTSANAKKIT SSTQLDVAGS
SSGQLVTSEC KTSSQEDGDS QIEMTSFSVS TTETNDQGSL NHDSFKKVSS NIEEQFSKDD
DIIVSKSKPS PSITSSVVYQ FPPVPCKEDP SLKVEDLSYL LVKSELEQLI SKNHLDCGNL
SLLTDFFVKH PSVRLKDTSL SNRYKGCAYN LLAELLKFLK THNILEELGS YHSEFMELLQ
DAHSFGFDKD WLDGVERRAL FPDIQVSQDA LQKLLDSKQQ VTKDVEALRL KIGILSQXKN
LINN
//
