ID A0A072V2Z0_MEDTR Unreviewed; 983 AA.
AC A0A072V2Z0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=ER membrane protein complex subunit 1 {ECO:0000256|ARBA:ARBA00020824};
GN Name=25490115 {ECO:0000313|EnsemblPlants:KEH36041};
GN OrderedLocusNames=MTR_3g110140 {ECO:0000313|EMBL:KEH36041.1};
GN ORFNames=MtrunA17_Chr3g0139991 {ECO:0000313|EMBL:RHN70851.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH36041.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH36041.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH36041.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH36041,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH36041.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH36041.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH36041,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH36041}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH36041};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|EMBL:RHN70851.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN70851.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|ARBA:ARBA00011276}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the EMC1 family.
CC {ECO:0000256|ARBA:ARBA00007904}.
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DR EMBL; CM001219; KEH36041.1; -; Genomic_DNA.
DR EMBL; PSQE01000003; RHN70851.1; -; Genomic_DNA.
DR RefSeq; XP_013462006.1; XM_013606552.1.
DR AlphaFoldDB; A0A072V2Z0; -.
DR STRING; 3880.A0A072V2Z0; -.
DR PaxDb; 3880-AES83586; -.
DR EnsemblPlants; KEH36041; KEH36041; MTR_3g110140.
DR GeneID; 25490115; -.
DR Gramene; KEH36041; KEH36041; MTR_3g110140.
DR KEGG; mtr:25490115; -.
DR eggNOG; KOG2103; Eukaryota.
DR HOGENOM; CLU_005034_2_0_1; -.
DR OrthoDB; 37872at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR Proteomes; UP000265566; Chromosome 3.
DR GO; GO:0072546; C:EMC complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR026895; EMC1.
DR InterPro; IPR011678; EMC1_C.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21573:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR21573; UNCHARACTERIZED; 1.
DR Pfam; PF07774; EMC1_C; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR SMART; SM00564; PQQ; 3.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..983
FT /note="ER membrane protein complex subunit 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014500292"
FT TRANSMEM 950..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 765..982
FT /note="ER membrane protein complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07774"
SQ SEQUENCE 983 AA; 110218 MW; F7D3BCB0217AFF2B CRC64;
MAMAIRVFLS FLLFLSLTNL ASSLYEDQVG LMDWHQQYIG KVKHAVFHTQ KTGRKRVLVS
TEENVVASLD LRHGEIFWRH VLGTNDVVDG IDIALGKYVI TLSSDGSILR AWNLPDGQMV
WESSLQGSKE SKSILNIPKN LKADKDDLIL VFGKGCLHAI SGIDGEVLWR KDFASESIEV
SHIIQSPEVI YVAGFVGSSK FYVYEVNAKS GELLKNNHVA LPFATSGESL SVSGDKFVVL
DDVRSKIVTI DINNGNINYN QKQVSDLIKD SSGQAVILPS KLPGLFALKI NSQVLLIKVT
NEGELVALDQ IDNTAAFSNA LSISEDQHVF AFVQYEDNKI QLSVKDVNDW NGALLKENLV
IDHQRGNIEK IFINNYVRTD RSHGFRALMV MEDHSLLLVQ QGEIVWSRED GLASVVDVTT
SELPVEKEGV SVAKVEQNLF EWLKGHVLKL KGTLMIASAE EKIAIQKLRL RSSEKSKMTR
DHNGFRKLLI VLTRAGKVFA LHTGDGRIVW STTLHALRKS EDCEHPVGLN IYQWQVPHHH
ALDENPSLLV IGRCGPSVTA PTVISFLDAY TGKELNSLSL AHTVARVIPL PYTDSTEQRL
HLIIDVNKHA YLYPRTPEAI EILKREFSNI YWYSVETDNG VIRGHALKSN CIHEIVDEYC
FVFRDLWSIV FPSESEKIIA TVTRKSNEVV HTQAKVMTDH DVMYKYISKN ILFVANAAPK
ASGEIGTATP EEATLVIYII DTVTGRILHR MTHHGCQGPV HAVFSENWVV YHYFNLRAHR
HEMSVIEVYD QSRADNKDIW KFVLGKHNLT SPISSYYRPE ISAKSQSYFF THSVKAIEVT
STAKGITSKQ LLIGTIGDQV LALDKRFLDP RRTLNPSQAE KEEGIIPLTD SLPIISQSYI
THSLKVEGLR GIVTVPAKLE STSLVFAYGV DLFFTQIAPS RTYDSLTEDF SYALLLLTIV
ALVAALFVTY VLSERKDLEE KWR
//
