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Database: UniProt
Entry: A0A072VBZ9_MEDTR
LinkDB: A0A072VBZ9_MEDTR
Original site: A0A072VBZ9_MEDTR 
ID   A0A072VBZ9_MEDTR        Unreviewed;       685 AA.
AC   A0A072VBZ9;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 12.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=11411441 {ECO:0000313|EnsemblPlants:KEH39307};
GN   OrderedLocusNames=MTR_2g093210 {ECO:0000313|EMBL:KEH39307.1};
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae;
OC   Trifolieae; Medicago.
OX   NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH39307.1, ECO:0000313|Proteomes:UP000002051};
RN   [1] {ECO:0000313|EMBL:KEH39307.1, ECO:0000313|EnsemblPlants:KEH39307, ECO:0000313|Proteomes:UP000002051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A17 {ECO:0000313|EMBL:KEH39307.1}, and cv. Jemalong A17
RC   {ECO:0000313|EnsemblPlants:KEH39307,
RC   ECO:0000313|Proteomes:UP000002051};
RX   PubMed=22089132; DOI=10.1038/nature10625;
RA   Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B.,
RA   Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H.,
RA   Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M.,
RA   Cheung F., De Mita S., Krishnakumar V., Gundlach H., Zhou S.,
RA   Mudge J., Bharti A.K., Murray J.D., Naoumkina M.A., Rosen B.,
RA   Silverstein K.A.T., Tang H., Rombauts S., Zhao P.X., Zhou P.,
RA   Barbe V., Bardou P., Bechner M., Bellec A., Berger A., Berges H.,
RA   Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA   Deshpande S., Dai X., Doyle J.J., Dudez A.-M., Farmer A.D.,
RA   Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S.,
RA   Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A.,
RA   Humphray S.J., Jeong D.-H., Jing Y., Jocker A., Kenton S.M.,
RA   Kim D.-J., Klee K., Lai H., Lang C., Lin S., Macmil S.L.,
RA   Magdelenat G., Matthews L., McCorrison J., Monaghan E.L., Mun J.-H.,
RA   Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA   Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C.,
RA   Sallet E., Samain S., Samson N., Sanders I., Saurat O., Scarpelli C.,
RA   Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S.,
RA   Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B., Wang K.,
RA   Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D.,
RA   White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F.,
RA   Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D.,
RA   Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.;
RT   "The Medicago genome provides insight into the evolution of rhizobial
RT   symbioses.";
RL   Nature 480:520-524(2011).
RN   [2] {ECO:0000313|EMBL:KEH39307.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A17 {ECO:0000313|EMBL:KEH39307.1};
RX   PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA   Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA   Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA   Schwartz D.C., Town C.D.;
RT   "An improved genome release (version Mt4.0) for the model legume
RT   Medicago truncatula.";
RL   BMC Genomics 15:312-312(2014).
RN   [3] {ECO:0000313|EnsemblPlants:KEH39307}
RP   IDENTIFICATION.
RC   STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH39307};
RG   EnsemblPlants;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CM001218; KEH39307.1; -; Genomic_DNA.
DR   RefSeq; XP_013465272.1; XM_013609818.1.
DR   EnsemblPlants; KEH39307; KEH39307; MTR_2g093210.
DR   GeneID; 11411441; -.
DR   Gramene; KEH39307; KEH39307; MTR_2g093210.
DR   Proteomes; UP000002051; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002051};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    418    445       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    466    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    585    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    637    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    667    684       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   685 AA;  78270 MW;  394F383CCF702F0D CRC64;
     MEKFIDNLPP MDLMRSEKMT FVQLIIPAES AHRAVSYLGE LGLLQFRDLN ADKSPFQRTF
     VNQVKRCAEM SRKLRFFKDQ VNKAGLMSSS RTLLQPDIDL EDLEVHLAEH EHELIEMNSN
     SDKLRQSYNE LLEFKIVLQK ACGFLISSHG RAVSGEIELQ DNVYSNDDYI ETASLLEQEM
     RPQPSTSGLR FISGIICKSK ALRFERMLFR ATRGNMFFNQ APAGEQIMDP ITTEMIEKTV
     FVVFFSGEQA RTKILKICEA FGANCYPVPE DISKHGQITR EVTSRLTDLE ATLDAGIRHR
     NKALSSIADH LAKWMDLVRR EKAVYDTLNM LNFDVTKKCL VGEGWCPMIA KTQMQEALQR
     ATFDSNSQVG IIFHQMDAVE SPPTYFKTNT FTNPYQEIVD AYGVARYQEA NPAVYTTVVF
     PFLFAMMFGD WGHGICLLLG ALILIAHENK LSTQKLGSFM EMLFGGRYVI LLMSLFSIYC
     GLIYNEFFSV PFHIFGPSAF RCRDTSCSDA HTIGLVKYRD PYPFGVDPSW RGSRSELAFL
     NSMKMKMSIL FGVAHMNLGI ILSYFNARFF GSSLDIRYQF VPQMIFLNSL FGYLSLLIII
     KWCTGSQADL YHVMIYMFLS PTDELGENQL FWGQRPLQIV LLLLAIIAVP WMLFPKPFIL
     KKLHTEVPLL LAFCMIFLLG SIEFY
//
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