ID A0A072VDZ9_MEDTR Unreviewed; 1580 AA.
AC A0A072VDZ9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:KEH40037.1};
GN OrderedLocusNames=MTR_1g019550 {ECO:0000313|EMBL:KEH40037.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH40037.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH40037.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH40037.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH40037,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH40037.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH40037.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH40037,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH40037}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH40037};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001217; KEH40037.1; -; Genomic_DNA.
DR RefSeq; XP_013465998.1; XM_013610544.1.
DR EnsemblPlants; KEH40037; KEH40037; MTR_1g019550.
DR Gramene; KEH40037; KEH40037; MTR_1g019550.
DR Proteomes; UP000002051; Chromosome 1.
DR ExpressionAtlas; A0A072VDZ9; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 3.40.1170.20; tRNA intron endonuclease, N-terminal domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF219; ARCHAEAL ATPASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 8..172
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1580 AA; 179774 MW; 9FE4EDF39759B6CE CRC64;
MASSSSSFTY DVFLSFRGTD TRYTFTGHLY KALHNKGIMT FIDDDHLQKG DQITPSLLKA
IENSRIAIVV LSKNYASSSF CLQELCKILE NGGLVWPVFY EVEPSNVRKL SGSFGEAMAV
HEVRYSDDVD RLEKWKKGLY QVANLAGFHY KNGDGYEHEF IGKIVEQVSR EIKPLTIPVV
EYRVGLEPQR KNVLSLLNVG CDDRVAKENS EKHGLIYLQK IILLEIIGEK EIELTSVKQG
ISVIQQRLRK KKVLLLLDDV DEQKQLDAIA GGNDWYGLGS RVIITTRDKG LLLSHGVEST
YEVHELNKKD AFELLRQKAF KTNKVCPNYA DVLNRALTHA SGLPLALEVI GSHLFHKTVE
QCKSTLDRYE RIPDKKMQTL LKVSFDALEE EEKSVFLDIA CCFKGYDLTI VNKMLHAHHG
DNMEDHMQVL VEKSLIKITE SRSVTLHDVI EDMGKEIVRQ ESPKEPGKRS RLWCPEDIVQ
VLEENTGTSK IEIIYLDSSI EVKWDEEAFK KMENLRTLII RHGAFSESPK YLPNSLRILE
WRKYPSGGVP SDFYPKKLAI CKIAFDFTSF VWGDFLKKKF QNMKVLNIDN CGFLARMPDI
SGLLNLEELS FQYCENLITM DDSVGLLAKL KILRVGSCKK LKSLPPLKLV SLEELDLSYI
DSLESFPHVV DGFLNKLQTL SVKNCNTIRS IPPLKMASLE ELNLLYCDSL ECFPLVVDGL
LEKLKILRVI GCSNIKSIPP FKLTSLEELD LSYCNSLTSF PVIVDGFLDK LKLLSVRYCC
KLKNIPPLKL GALEQLDLSY CNSLESFPPV VDGLLGKLKI LKVFCCNSII SIPPLKLDSL
KELHLSYCDS LENFQPVMNG LLKKLQFLSI KSCINIKSIP PLQLTSLEEL DLSNCQSLES
FPPVVDQLLE NLKFLSIRYC HKLRIIPPLK LDSLELLDIS YCDSLDSFPH VVDGMLEKLK
IMRVKSCSNL KSIPPLKLAS LEELDLSYCD SLESFPTVVD GFLGKLRVLS VKGCNKLKSF
PPLKLASLEV LDLSYCDNLE SFPLLVDGFM DKLQFLSIIY CSKLRSIPPL KLALLEHFDL
SYCDSLVSFP PVVDGMLEKL RIFRVISCNR IQSIPPLKLT SLEELNLTYC DGLESFPHVV
DGLLGKLKVL NVRYCHKLKS IPPLKLDSLE QLDLSYCDSL KSFPPIVDGQ LKKLKILRVT
NCSNIRSIPP LNLASLEELN LSYCHNLECF PLVVDRFPNN LKVLSVRYCR KLKSIPPLKF
ASLEVLDLSY CDNLESFPKI LGEMENIRQV HLYTTPIKEL PFSFQNLTRL RTLYLCNCGI
VQLPSSIVMM QELDELIIED GGWLFQKEDQ GDKEVISMQS SQVEFLRVWN CNLSDESLAI
GLMWFANKLF LDNCENLQEI KGIPPNLKTF SAINCISLTL SCTSKFMNQE LHESGNTSFV
FPQAEIPKWI DHQCMQGLSI SFWFRNKFPA IVLCVVSPLT RDNYQPNVKV FINGKTFFYR
DVEADYEWPI SFHLHIFHMQ IEKFNDDVDA ALLENEWNHV VVDFGFEFHK SGIHVLKEKS
SMMDIQFTNP ENDVNMGVTL
//
