ID A0A073CLU8_PLAAG Unreviewed; 505 AA.
AC A0A073CLU8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=A19Y_4636 {ECO:0000313|EMBL:KEI69264.1};
OS Planktothrix agardhii NIVA-CYA 126/8.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Microcoleaceae; Planktothrix.
OX NCBI_TaxID=388467 {ECO:0000313|EMBL:KEI69264.1, ECO:0000313|Proteomes:UP000027395};
RN [1] {ECO:0000313|EMBL:KEI69264.1, ECO:0000313|Proteomes:UP000027395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIVA-CYA 126/8 {ECO:0000313|EMBL:KEI69264.1,
RC ECO:0000313|Proteomes:UP000027395};
RX PubMed=24907328; DOI=10.1128/AEM.01188-14;
RA Christiansen G., Goesmann A., Kurmayer R.;
RT "Elucidation of insertion elements encoded on plasmids and in vitro
RT construction of shuttle vectors from the toxic cyanobacterium
RT Planktothrix.";
RL Appl. Environ. Microbiol. 80:4887-4897(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM002803; KEI69264.1; -; Genomic_DNA.
DR RefSeq; WP_042158029.1; NZ_CM002803.1.
DR AlphaFoldDB; A0A073CLU8; -.
DR STRING; 388467.A19Y_4636; -.
DR PATRIC; fig|388467.6.peg.4577; -.
DR eggNOG; COG0827; Bacteria.
DR HOGENOM; CLU_043528_0_0_3; -.
DR Proteomes; UP000027395; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KEI69264.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000027395};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KEI69264.1}.
FT DOMAIN 14..193
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 505 AA; 58144 MW; A9EA72403592E674 CRC64;
MVAPTNRKQD KFQSYYTNCD HITSYMVGLL ECDNNMSVLE PCAGEGVFID ELLKQELTPE
ITAYELNIDA VNQLNIKYNN LKNIEIIHQD FILANTNKKF DRVIANPPYG AYQSPEKRKQ
LKKAYPHIYA KETYGLFLIR TMELLKQDGR LVFIIPDTYL SLHHHQGLRK EIISNYKIES
ITLFPSDFFP GVNFGYAGLS IISIVKEKPN IDYNFPVYKG LHSPPELTEL LTKTKKNYEV
CRLSYHQLIN NPSQAFFLSS KDWISQILSS DNMTVGDICF VVTGFYSGND GKYLRRSPSV
TRGTKKYAIV ENNKICRDNL SINPPLNGIK NDCYWVPIVK GGNQRFYKQS EWFMDWGEKA
VHDYKVTNKQ KARFQNSQFY FRQGIAVPMI SSSSITGSLL DGRLFDQSIV GIFPRQDYQD
LIYYLLGFFN SKACNDLIRT INISTNNSAN YIKKIPLIIP QKQLLETILK EVGRLVILSK
SNIINDQDLQ KLNEYFYDVY GAKIS
//
