ID A0A074X3X5_9PEZI Unreviewed; 299 AA.
AC A0A074X3X5;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:KEQ76722.1};
GN ORFNames=M436DRAFT_38013 {ECO:0000313|EMBL:KEQ76722.1};
OS Aureobasidium namibiae CBS 147.97.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043004 {ECO:0000313|EMBL:KEQ76722.1, ECO:0000313|Proteomes:UP000027730};
RN [1] {ECO:0000313|EMBL:KEQ76722.1, ECO:0000313|Proteomes:UP000027730}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 147.97 {ECO:0000313|EMBL:KEQ76722.1,
RC ECO:0000313|Proteomes:UP000027730};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
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DR EMBL; KL584703; KEQ76722.1; -; Genomic_DNA.
DR RefSeq; XP_013430738.1; XM_013575284.1.
DR AlphaFoldDB; A0A074X3X5; -.
DR STRING; 1043004.A0A074X3X5; -.
DR GeneID; 25408942; -.
DR HOGENOM; CLU_023205_0_3_1; -.
DR OrthoDB; 5305445at2759; -.
DR Proteomes; UP000027730; Unassembled WGS sequence.
DR GO; GO:0016652; F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor; IEA:InterPro.
DR CDD; cd19120; AKR_AKR3C2-3; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044494; AKR3C2/3.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000027730}.
FT DOMAIN 25..279
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 64
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 119
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 89
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 299 AA; 33030 MW; E872EEEC112CAFFB CRC64;
MANIHTPIPN LKLNDGNSIP MLGYGTGTAW YKTGDESTLD QACVDATKTA IKLGYYHLDG
AEVYKTEPEL GKAIAESGVE RSKLFVTTKV LPNIADVPAA LNTSLKKLQL EYVDLYLIHA
PFFGSPEESP EALQKAWKAM EEVKEAGLTK SIGVSNFLPQ HLDAILQTAR IPPAINQIEF
NAYLQHPELL KYHKEKGIAT EAYGPLTPAT KAAPGPLDNV LAGLSKKYAV SPGEICLRYC
IDQDIVPITT SSKEQRLSDY LRAMTFKLTP REVNDLNEAG SQKHFRGFWN HKFAADDRR
//
