ID A0A074YB35_AURPU Unreviewed; 1179 AA.
AC A0A074YB35;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=M438DRAFT_397589 {ECO:0000313|EMBL:KEQ84061.1};
OS Aureobasidium pullulans EXF-150.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043002 {ECO:0000313|EMBL:KEQ84061.1, ECO:0000313|Proteomes:UP000030706};
RN [1] {ECO:0000313|EMBL:KEQ84061.1, ECO:0000313|Proteomes:UP000030706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-150 {ECO:0000313|EMBL:KEQ84061.1,
RC ECO:0000313|Proteomes:UP000030706};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KL584983; KEQ84061.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A074YB35; -.
DR STRING; 1043002.A0A074YB35; -.
DR HOGENOM; CLU_002472_1_0_1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000030706; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000030706}.
FT DOMAIN 1010..1026
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 130845 MW; 9BCFAC7D4146E54D CRC64;
MARGIEGNEI ATPRVPKLQK STSSASQSAK QQKSILGFFQ RKTAPASSPA APSDIVAASS
PPPQSSPAPA NFNGKENVPL VKPSIPSSSP VRNGKKKINY AESDDEDEEP VLRQRSSNAT
GRSIKRRKLD DDSDDEFEMD DATEALMAAA DNVEMQDFVV DDASEDDAPI RRKKSSQPRK
PSKQPSPIAE DEPSQSPEIP STSTAQQWNF DPDNVEPYAS RKTPQRKPQS GPAKKQKAHM
SEPDSRYPWL ADIMDADRNK PSSPDYDPRT LYIPPLAWSK FSPFEKQYWE IKSKFWDTIV
FFKKGKFYEL YENDATVGHQ LFDLKMTDRV NMRMVGVPEA SLDHWANQFV AKGFKIARVD
QMETALGKDM RERDEKTGKG GKPKKEEKVI RRELASVLTS GTLTDGGMLQ DDMSTYCAAI
TEREVDGLPA FGIAFVDTAT AQFQLCDFVD DVDMTKFETF VAQTRPGELL LEKSYISSKA
VRILKNNTSP TCLWNYLKPD KEFLTADKTA LKITGEHYFE SEKDSGDDAW PTLLREAREK
ELCFSALGAL IWYLQTLKIE RDLISLGNFD WYDPIRKATS LVLDGQSLIN LEIFANSYDG
GVEGTLFAML NRCITPFGKR MLRQWVCHPL ADTAKINARL DAVEALNADL TITDRFTASL
SKIPDLERLI SRVHAGRCKA SDFVKVLEGF EQIEYTMSLL SGFGEGEGVL GQLISSMPDL
AGTLAHWTDA FDRDQAKEQN LLVPQAGVEE DFDESQGTID EIEGKLQSLL KRCRDELGTS
AAKYTDNGKE IYQIEVPIKT KNVPKNWKQM SSTAKAKRYY FPELESLIQD LKEAQETHGQ
IVKQVAGRFY ARFDEDYAIW LAAVKIVAHL DCLISLSKAS ASLGEPSCRP EFVESERSVL
EFSDLRHPCM LNTVSDFIPN DIALGGDNPS IDLLTGANAA GKSTVLRMAC IAVILAQVGC
FVPCVAARMT PVDRIMSRLG AHDNILAGQS TFMVELSETK KILSEATPRS LVILDELGRG
TSSHDGVAVA QAVLHHVATH TGCLGFFATH YHSLAAEFSS HPEISPKRMA IMVDDTERRI
TFLYKLEAGV AEGSFGMHCA AMCGIPDAVI QRAEDAAKEW EYTGRLQVRA EERKEGELPL
GLLSDIAWML KTADNEVPEG EQCIGERGLE VLRRTIAAL
//
