ID A0A074Z6V9_9TREM Unreviewed; 1792 AA.
AC A0A074Z6V9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=SET domain protein {ECO:0000313|EMBL:OON14105.1};
GN ORFNames=T265_10344 {ECO:0000313|EMBL:KER21302.1}, X801_10108
GN {ECO:0000313|EMBL:OON14105.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER21302.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER21302.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OON14105.1, ECO:0000313|Proteomes:UP000243686}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Khon Kaen {ECO:0000313|EMBL:OON14105.1};
RA Mitreva M.;
RT "Draft genome of the nematode, Opisthorchis viverrini.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KL596977; KER21302.1; -; Genomic_DNA.
DR EMBL; KV906880; OON14105.1; -; Genomic_DNA.
DR RefSeq; XP_009174953.1; XM_009176689.1.
DR STRING; 6198.A0A074Z6V9; -.
DR GeneID; 20324512; -.
DR KEGG; ovi:T265_10344; -.
DR CTD; 20324512; -.
DR OrthoDB; 950362at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR Proteomes; UP000243686; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19172; SET_SETD2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR038190; SRI_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 891..945
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 947..1065
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1072..1088
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1618..1651
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..98
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..383
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1792 AA; 198230 MW; 633F614F1D356958 CRC64;
MEYDPASPTD EPEDPLPDVD LSSIPLPGIR ILPSVECGDV STITTCITDI PLPPTDLKAS
EIPLPPAPVA VQYAPYFSEH SLPAVPPPPP PPPPAATNYS EPDSASVPLK FSLRSSAKGL
GQDVSGEPSG VFESSKDLKT SEPRAMPKLQ ALMKRSKPSK LTVGVLPSKT KLPASETKTE
LFLPTKESDE NNGVTAALEV AASLASTINS SGLQSAPSNP TSDPNELLTN AMKEVSALNS
LVHMASTGNL AQIAVEASRA ELSAHLPSTL SSANNSAAHI PNLMSLTVQP VQPTPQPTAL
SADPTSVLRQ PKMNLANMQF VNPQKLRSAQ MIATPLIANP AIAAQPHHSD EQSKSRDSRR
RSRSRSRRRS HSGRRSSPNR RSRRHHSSSS DGSTPRHSSR GYQRRSRSRH SSEERYTKPR
RQSRGRDWDR RDRDRWREDS FESERRRRSD RSFGERRTAA RVSPISRYSE RSRRRSDSHD
RSWRNRLSRR SPDRDKRADS RDRDRFSRNE ADRRRSKPAE RKRSRSPSER EDVERKRRKS
SSEQRPADKI GQKSKDVRID QTRVDNHNQG IASSDSEAES SDTSESSSDS HRSKSSGAPV
AEKSSPKKSV RPRSVSSKES SDSSPMQDAM KDDCQEADDL PTSEPSPAKS LSTRESELIN
ASLHPRNAGV GSVSPVAPSQ QDESDAMDLA SDTEVGSADT GSPGPVSIAQ LCSDDVFCGN
TPEQSASHVN SDADLTGIQH STVPSGGPPS SSAHELSSPN TVRLDSTLEP IAAVTNLMVD
TSPQPSPAHS IPGRVEGKYD LRERKTKENR ATDRELDRLL SAMFADLARS EPSSEVFDSH
PEAPRPEYQH IVENDYSRIE RINMTTMQNK VDGTAKASLL GSTASLTHHE MRRWICDCAT
PSVEEIRAGI FPCGPGCINR ALNIECGPSC PAGEFCHNRQ FQKRLYAPTE PFYCGPGKGW
GLRTTSPVKR STFIIEYVGE VIDFTEFRRR IRRYEKLGHA HHYFMALESD RFIDAGAKGN
WARFVNHSCE PNCVTQKWSV DGEIRIGFFA REDIKAGEEI TIDYQFVQFG ASEQKCYCGK
PTCSGIMGST SKTLQDKVRL KDTSVVERRV MQLLQRDSFQ RADDITLVLQ VMVQECLTRY
TRMELLKRLA ATHSVACLKL FRQYNGLDML AAFMCDSHVD DWELKRQILL CLDHIPVSEQ
KQVQSNSRLM DIVAQWAVDP HYCRRRCTSP GDAQTPHNDS NMTGNGRNGD NAEHNILSGG
SRHLVVEMEG IGFPAPATPV GNVTMSQQVG EYIPENGYVG GTSPVQLIVG GVFDSYPSTP
GSTQSSVLSQ VTTQSSSLTA SDVHASSNLS SNPSVSGTNC EVSLGSAYVD VETGEVEPPM
LPNSASNSKE STSLPDEAEW IREIRQLALQ LIEKWSKLPK ENYRIPRTER QETEKELHFP
NHTGSCLVSW GHNDETDHSV TSWGQPNNKK FSSSRSRRST ENPSCNLSSL STETNTRKLT
KMERRKLFEA QVCAAESKTD DSTPDPPQPS AFGSDNLDEV ETLRQLILCS LLEELKKTGP
DLSKFGTPGS EEGRTAVLLN TLLQTLPSLL SKLTTTNDIS AINRLCQELQ KRKADPVNVL
PAGWQSAVDP SGRIYYYNMS TKVVQWEKPG CRDGNDHNKL GSTEPSEKST QPVLSADVRK
QMEKDFTQEV GKFILRLLRP YRLPNCMTGR IESNEDLVHV TRKMTHAFVS KELLRCRYTM
PPTLTETLQD RIRTSLTRYM TSRGAVYRRG KKALSTQPAI TSISSKSETP AT
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