ID A0A074Z744_9TREM Unreviewed; 646 AA.
AC A0A074Z744;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Ligand-gated ion channel {ECO:0008006|Google:ProtNLM};
GN ORFNames=T265_10270 {ECO:0000313|EMBL:KER21397.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER21397.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER21397.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KL596970; KER21397.1; -; Genomic_DNA.
DR RefSeq; XP_009174854.1; XM_009176590.1.
DR AlphaFoldDB; A0A074Z744; -.
DR GeneID; 20324438; -.
DR KEGG; ovi:T265_10270; -.
DR CTD; 20324438; -.
DR OrthoDB; 2957060at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF00060; Lig_chan; 2.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 193..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..539
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 90..146
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 594..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 365..392
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 594..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 72801 MW; C2377D9246DD248A CRC64;
MIYLNPNCTV FAKYTHLQFN SVFTRDSTES VVYDILQLNV LHTGRLIFQL ARFSRYRTSV
YPLLHQRTLD AFEFSRLNRR TYSRLSHDPP FVIKTEDGWT GYSVEVFERI ADALGLDYVY
IEQLDHIYGV KLPNGQWNGV IGEIASKHAD VGLGPIVQDG ERKLVVDFTI PYYVSAGLAM
VVSTKTDQEL GPFFFLEVFT GPVWICCISA VVFVSLLVYA LDRFSPYSFQ NQALKDNGAS
EAGTMFTLKE SVWYVLGACT QQALTILIYF IRPVWICCIS AVVFVSLLVY ALDRFSPYSF
QNQALKDNGA SEAGTMFTLK ESVWYVLGAC TQQGESLDPR STSTRILITG HWIFVVIMVS
MFSANLSAKL TVSGLKEEIK SLEQLAGQTE VKYTLRSNSA EYAFFRKMYG VEESLFRIWR
YLSSNLTEFS SNYSVWQYPI TERYGTIFKR MEEWGFTHDT VDSLDHVRKG WVVFMESSLA
AYHIASACDL KELGERIGSW DYGIALPLKS FLTPNMNSMI LHLKAENILD DLEHKWWSAN
TTGCPEPSTS IGFGLEQVGG MFIILACGFL SAALILGMEL LFYRVIMKRL RKGNKTAPME
EEKPADKMNA RGEQGGLPPP ALVVTPPDCV NVNDDSGAPP PYAQNP
//
