ID   A0A074ZG05_9TREM        Unreviewed;       518 AA.
AC   A0A074ZG05;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Choline O-acetyltransferase {ECO:0000256|ARBA:ARBA00040495};
DE            EC=2.3.1.6 {ECO:0000256|ARBA:ARBA00039091};
GN   ORFNames=T265_06479 {ECO:0000313|EMBL:KER26196.1};
OS   Opisthorchis viverrini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX   NCBI_TaxID=6198 {ECO:0000313|EMBL:KER26196.1, ECO:0000313|Proteomes:UP000054324};
RN   [1] {ECO:0000313|EMBL:KER26196.1, ECO:0000313|Proteomes:UP000054324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA   Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA   Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA   Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT   "Opisthorchis viverrini - life in the bile duct.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   EMBL; KL596753; KER26196.1; -; Genomic_DNA.
DR   RefSeq; XP_009170017.1; XM_009171753.1.
DR   AlphaFoldDB; A0A074ZG05; -.
DR   STRING; 6198.A0A074ZG05; -.
DR   GeneID; 20320658; -.
DR   KEGG; ovi:T265_06479; -.
DR   CTD; 20320658; -.
DR   OrthoDB; 1429709at2759; -.
DR   Proteomes; UP000054324; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF14; CHOLINE O-ACETYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Neurotransmitter biosynthesis {ECO:0000256|ARBA:ARBA00022979};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT   DOMAIN          1..475
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        205
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   518 AA;  59280 MW;  A885EC10B9BE12DB CRC64;
     MCMEQYYRLF TSYRYPGKTK DTLVTTSDND PFDPEHIIVV CLDQFFVMEV IFNGTRLSEE
     DIYNQLRRIT QFAEEAVSGD NDLGVQPRVG ALTALPRNEW AEVWERMAKD PQNQANLKAI
     TKSMFVLCLD QPIGPVRELD EEANLNGSID DLAEAPAEYR RDDVSLALQL LHGFGSKYNA
     ANRWYDKTMQ FIVSRDGNCG LNYEHSVAEG IAVIRLTEHI LEYMQEVKRW RLVRFPSVCD
     LAFPKRLEWN LDEKTQGVIT KALREIDQIA EDLDLYILRY NEYGREFPKT VNMSPDSFIQ
     LALQLAHYKL HNYLVPTYES ASTRRFVLAR VDNIRACSMP ALEWCKAMTG QTRCTTDEKI
     RLLRKAMEWQ TEIMLETILG HGVDNHLLGL RQIAIEHDGK LPKIFTDETY MEANRFRLST
     SQVPTTMDAF MCYGAVVPNG YGAAYNPHPN YIVTVISCWR TNPENSAAKF AEMLTAAFTE
     MRDLVLSNPQ LAKEMSKEPV EWSIARSLGA DMTSSSAV
//