ID A0A074ZZG3_9TREM Unreviewed; 3063 AA.
AC A0A074ZZG3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN ORFNames=T265_02321 {ECO:0000313|EMBL:KER31407.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER31407.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER31407.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; KL596646; KER31407.1; -; Genomic_DNA.
DR RefSeq; XP_009164799.1; XM_009166535.1.
DR STRING; 6198.A0A074ZZG3; -.
DR GeneID; 20316509; -.
DR KEGG; ovi:T265_02321; -.
DR CTD; 20316509; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21311; CH_dFLNA-like_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 20.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF18; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 17.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 20.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 21.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 21.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 152..258
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 274..377
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 384..480
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 482..582
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 790..887
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 887..978
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 982..1094
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1145..1237
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1509..1602
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1607..1706
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1707..1802
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1803..1910
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1911..2031
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2060..2132
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2149..2233
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2233..2332
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2330..2418
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2421..2513
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2511..2611
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2614..2706
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2726..2832
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2834..2926
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2968..3062
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1342..1367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3063 AA; 333415 MW; 4C356BDBF4368F4A CRC64;
MVFHRVHTIK LRSGILFPSA VQPFYCRCSV PFRGVTDEVT ARICKARAAC ANMRHIWRQS
DVSLNHKGRV HQATMQAASL YGCAPWPIRA AELRSLQVFD NRCLRTIARP IRMEDRPARH
PVAADEAGNS VPVDDHSRMA EKELAEDAQW KLMQRNTFTR WANEHLKKAN MHIDNLETDL
CDGLRLAALV EVLTNHKFKQ LNKKPTFRTQ KLENVTKVLK FLEDNEKLRL VSIDSTHIVD
SNMKLILGLI WTLIMHYSIS LPMWDGDSAI QDDKGPKQRL LGWIKQKMPE PPIKNFTTDW
NSGVAIGALV DSCAPGLCPD WCKWDPRHCL KNATEAMTMA EEWLNVPQLI RPEEMINPRV
DEKAMMTYIS QFPSAHLKEG APLRPKLDPG RVRAYGAGLE HKGNRINQPC RFNVDTAEAG
SGQLEIILLN PKGVRIPCEV VPDKNASYSC TYQPTMEGEH RVIIRYAGQE IRGSPFSVSV
EPPIGDPLKV IISGPGIQPT GGNSVGRRSY FTVDTKRAGM GTVECFVVDP HGRRDSVEPR
ITQPEGEGVF LVEYTPRDVG RHQIFINFGG QKLPNSPYVV TVGPPAAVAA LSAIVTMVEQ
VPKSSSNGEK TKHDITVVTP PISRLLSDRL HSPLALVSTD VLHAEQLNGP SEQTEKLQHS
SKDLTKSNGT VQCNGQHTAV ENGHNVSQDT NHMNVYLAVD LHAVYLRGQG ILPCFDRLPC
SSMTSSSSDF LLVGAESPVG NGIHDSSSLC HGETFCATGQ NVENASNPDH VALPDSEFME
SVWQLREDKP REFNPEFAYA TGRGVRPRGI RAQDKVEFQI HTERCGNQAS LLATLIRQNG
ETEQVAVEQL DKDTWNCSYI PRRPGKYCLR VLYGGVDIQN SPFEIIVGPH KTSAIKATGP
GLVAGVVNHP IIFSVSCREQ SSKIGFSIEG PSEARMDCFN HGDGTARVTY WVTQPGEYAV
HILYEDEDIP GSPYMPNILP DSSDVFADRV RVYGPVIEMA KTKFALGKPV EMYIDGLKEA
LSTVAQRTLA DQKLDSVLHI ECHDALGTSV PVRYVRRADG SIVYSFTPTT PGTYTIFATV
LNIPLKGSPY RVNNFGRPVQ VDLSRQADGV YRIEYCPPPN VSDIYFTPML GSIPVSKSPL
HVMVRPAFDT SSIRIIGLEQ TVPINTEQQF NVLTCRPASS YVVSLLSVED PLVSLPCKVT
ETTDGLLVTF KARESGVFQA SIFSGGQTIT DPVTFTVINS QRVHVSIFAN DKSDIPEGTN
GFDLRPSETE LPTTVGVVSK EIMKPRFISF DSRYMKAFCL TESDVPPSEK NFVAEVSWDC
SLLKKANFND CLRPAEETSA SICNTHTSPD QCTKSNEPPS NASGESSLDG FAVMASLTKP
GKDDPPVRKL FNVRITGRSE TDCQDESLFS ENVDIHQIMT YTVLTDPVMQ QLEHQSSTTQ
LIDGSALAKG ESDDTTGSDG SSSNFGRYPP RPFITDIEKS CFTLAYRAFH SSLNHQTVLV
AKSSWPQCLP DHPASTVTAA GSGLERAVAT QISVFTIDSR SAPPAPLGVT VTGPSEAKII
CIDNGDGTCD VSYNPPLPGR YTISVIYNGE AHISGSPFFV QAYPVGKIDL STDEIRTHGV
GVEADGVYKA SYVKFTVDAS EIDKVGEGVI SAILTAPDGE RLACQTTNNN DGTYTCSYTP
LEEGAHQIDV SYEGVQVPGS PFNIRVIPGC DPNRVKVYGK GLENGPHLCP GESAEFTVDL
TGAGQGGLGL AVEGPSEAPI RCRDNRDGTC TVFYTPKEPG QYSIFVRFND TNVPNSPFYV
DVKTKVDPSQ VQCYGPGLES GLLRAGWPAY FTVDTKKAGD AKLQVRYTPK PGGETRPAHI
QPLGAAAGKD ISQPQHYHKI TYTPEAEGLC HIEVLYDGEH VPGSPFLVQI RKSCEPERVR
VLGPGVDGPV LASLPVTFTV DARDAGMGDL TLGLTDPRGQ SVPVRVVPLP VDNESIVTNG
AVPSVTSLAS GDVSDTGLLS CTYEPYLVGP HNIHVMFAGV EVDNSPFVIQ SVPTGRADLC
SIEDPISEIV PIETENVIRV NIAQGGTGRL TCQVVQPATK PGVSATLLPV ESEENSDGIV
SVYYTPKQLG ELCVELRFGG QLIPGGEFTQ KVVTREEAAK PAKATSQFRS VEFRLPAPRG
DADVECMVVR PSGTHQHVTP TINPDDTITI MYDPVEQGMH ELHVNGITRA KPGDIRSSTV
AMPLQGSPYR FFVDFVTTGH VTAYGPGLSH GVTNQPAEFT INTKDAGGVR ISSKIGGLSL
SVEGPSKAEI KCDEHDDGTC TVRYYPSAPG DYQVAIKFKD QHISGSPFPA KIIGDTYTRA
QLNLGATSDI ALEAFGDDIS TLTANVQSVS GREEPCVLKR LPNNRLGISF TPREIGEHLI
SVYQAGEHIT NSPFRIRISE KEIGDPRRVR VTGPGLISGV ANQPNHFTVD TRDAGYAGLS
LSIEGPSKAE IDCQDNHDGT CSVMYLPTEP GMYIINVKYA DVHVPNSPFT VDVGGKSLSR
VTERITRRRE ASTVTTVGSR CELSLRVADT TLRDMTASVT APSGDTYPCE IVQVDADHYN
IKFVPQEMGE HLVSVKHRGI NIAGSPFQFT VGPITDGVAH KVRATGPNLQ RGFTNAINEF
TIYTREAGAG TLAIAIEGPS RAGIDCVERA DGSSVVSYQV SLPGTYHCSI KFNDVHIPYS
PFAIQIADSG RTGRVASYAV PSQVSGLQET APVGSEEFPS QIGRPVAFTV HHQLVGGQVL
RARVQAPSGL IEEAGIQQVD RDQFVVRFVP MESGPHFVYV HIVPVEMNDM NVELGPGSPY
PPLEGSPFRL VISHQPADPS MVHANGEGLR RGRVGEKNTF FVHTANAGSG VLNVTVDGPS
KVTLTTQEQD EGYSFSYVPT APGSYEISIK YGGNHHINGS PFKAEITGSI RSPTVLNSRV
ADRTSNVVLE TIEKSIVDYQ ASRVSQNLRD NQADRVRCEG MGLKRADIQG VNYFTVDASD
AGTEILLVGI CGPTRPFEEV KVNHLGNNRY SVSYRVNEKG RHWLLVKWGD HHVPGSPFTV
DVP
//
