ID   A0A075A0T6_9TREM        Unreviewed;       888 AA.
AC   A0A075A0T6;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Calpain catalytic domain-containing protein {ECO:0000259|PROSITE:PS50203};
GN   ORFNames=T265_01947 {ECO:0000313|EMBL:KER31857.1};
OS   Opisthorchis viverrini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX   NCBI_TaxID=6198 {ECO:0000313|EMBL:KER31857.1, ECO:0000313|Proteomes:UP000054324};
RN   [1] {ECO:0000313|EMBL:KER31857.1, ECO:0000313|Proteomes:UP000054324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA   Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA   Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA   Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT   "Opisthorchis viverrini - life in the bile duct.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|ARBA:ARBA00007623}.
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DR   EMBL; KL596640; KER31857.1; -; Genomic_DNA.
DR   RefSeq; XP_009164349.1; XM_009166085.1.
DR   AlphaFoldDB; A0A075A0T6; -.
DR   STRING; 6198.A0A075A0T6; -.
DR   GeneID; 20316135; -.
DR   KEGG; ovi:T265_01947; -.
DR   CTD; 20316135; -.
DR   OrthoDB; 142935at2759; -.
DR   Proteomes; UP000054324; Unassembled WGS sequence.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00044; CysPc; 1.
DR   Gene3D; 2.60.120.380; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR10183; CALPAIN; 1.
DR   PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR   Pfam; PF01067; Calpain_III; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00720; calpain_III; 1.
DR   SMART; SM00230; CysPc; 1.
DR   SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00239};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}.
FT   DOMAIN          57..391
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   ACT_SITE        113
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        325
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        359
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   888 AA;  100274 MW;  ACC2A880942F3F32 CRC64;
     MTEAFAESPP ESKARECWFA TEAAYAQLGS RYDSELMKYR RQNADRLRQR SRKTGMLFVD
     PEFPAVRSSL TAETNNIRHL EIVWQRPSDL VSNPCFVAAN GPAACRQGRL GNCWFVAACA
     CLSLHKGVFQ KVVICTPPLN SWDAYCGVFE FRFWRFGTWV HVIVDDLLPT VNGELLYCSS
     YNSDEFWCSL LEKAYAKLLG SYEALEGGEL ADALIDFTGG LTECLEFNQT GTDLRLCVTP
     DLPPSLNVPL DESKLAVSLS CCGVSRQSAT LLHPVPVWKN KTLCEYIYKL LLRNQLTKTL
     IASAISTDDP DGCERETELG LIVGHAYAVT RLCAVPTKRS ADSGSSNDDS LVRLVRLMNP
     WGHGTAENGE FWMRFEDFLR QFNYVVLCYT PMGNGSLSGD SKAWFQFIPP IRMAPPDVVC
     HARDGRLVVV PSEYGHSLDS DRPSPLRLRE LWTDFTIHSC WTNEMSGGCL NCDDTFVNNP
     QFALDVPRRP STSLVIYLFQ KTERSPERLA STTGLYHIGM SVFRVEANRT VPIRSLNEPV
     HLVINSVYRN SRVVWLRLNR LPYGRYFVIP TTFYPNCLAE FMVRLVGSPP LLFFEVERTA
     PCLASPPIHR SKSVLLRRSY GKKIKDSGGC FRHWITTRQA VSPLKEDMSD FFGRVLLPPP
     SENLRLTILQ SVIWPPSTSF LARVLERQFE RIDERSLPPY YAHVSVNDQQ ASTGLYNLQL
     LKEGGGPGST GLIQFRESFL FPKNNKTGLS FRFQLRIHHP VFDEVHSEYT GILDSSPGSD
     KSQPIIRHVP LFGRLGPNKS HRQTTNYRER EHQICRIVSD PVSSSTVDSV CLPAVTKRQR
     AQNYRAAFQQ SELLLLDAGC SKLLPLTSQT REYFSDNRCG FLTLSLEC
//