ID A0A075A8U5_9TREM Unreviewed; 765 AA.
AC A0A075A8U5;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=T265_12857 {ECO:0000313|EMBL:KER32140.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER32140.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER32140.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
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DR EMBL; KL596637; KER32140.1; -; Genomic_DNA.
DR RefSeq; XP_009164156.1; XM_009165892.1.
DR AlphaFoldDB; A0A075A8U5; -.
DR STRING; 6198.A0A075A8U5; -.
DR GeneID; 20327025; -.
DR KEGG; ovi:T265_12857; -.
DR CTD; 20327025; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324}.
FT DOMAIN 104..270
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 295..475
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 734..762
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 87404 MW; E01BAD7C832F382C CRC64;
MSSRHRIDIG ESKPRKSRRS VVHLNGERYD ELDLETFTDG PDGYSNRERS RSPERNNSKA
HMPIPTSYSV QVNPYNGKPF SARYFDLFRK RIQLPVWEYK ENFFKVISEN QVTVLVGETG
SGKTTQIPQW CLEWITGRYP TKKAVACTQP RRVAAMSVAQ RVSEEMDVEL GQEVGYSIRF
EDCTSSRTVM KYMTDGMLLR EGMSDPLLEA YGVVLLDEAH ERTLATDILM GLLKEIIKQR
LDLKIVVMSA TLDAGKFQDY FLKAPLMTVP GRTHPVEIFY TPEPERDYLE AAIRTVIQIH
MCEEVEGDIL LFLTGQEEIE EACKRIQREV EGLGPDVGEL RCIPLYSTLP PNLQQRIFDP
PPPKRANGAI GRKVVVSTNI AETSLTIDGV VFVIDPGFAK QKVYNPRIRV ESLLVTAISK
ASAQQRAGRA GRTKPGKCFR LYTEKAYANE MQENTYPEIL RSNLGTVVLQ LKKLGIDDLV
HFDFMDPPAP ETLMRALELL NYLAALDDDG NLTDLGSMMA EFPLDPQLAK MVIASCDFNC
SNEVLSITAM LSVPQCFVRP ADAKKSADEA KMRFAHIDGD HLTMLNVYHA FKQNHEDPQW
CYDNFVNFRS LKSADNVRVQ LSRIMDRFCL RRSSTDFSSR DYYLNIRKAL VSGFFMQVAH
LERTGHYLTV KDNQVVQLHP STVLDHKPEW VLYNEFVLTT KNYIRTVTEV KPDWLVRIAP
QYYDMSNFPE CEAKRLLERI VQRIQNKRLQ QEQKQAQEAK AKVSA
//
