ID A0A075AI51_9TREM Unreviewed; 1873 AA.
AC A0A075AI51;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=T265_02697 {ECO:0000313|EMBL:KER31024.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER31024.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER31024.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL596652; KER31024.1; -; Genomic_DNA.
DR RefSeq; XP_009165263.1; XM_009166999.1.
DR STRING; 6198.A0A075AI51; -.
DR GeneID; 20316885; -.
DR KEGG; ovi:T265_02697; -.
DR CTD; 20316885; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF125; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324}.
FT DOMAIN 885..1110
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1241..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1455..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1584..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1811..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1673..1707
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1760..1790
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1345..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1816..1844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1850..1873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1873 AA; 207042 MW; FB0AE8A0B2FFE92C CRC64;
MGSFLGPDGL RKATLRTLSA KTQKIIIVQP QHAFGTWLPY HPKKARGLRY SQVAQIQLGA
LGMLWIVSNH GTSLISRRDN SINPALAATS APAVSFIVEF VKDIVASNPN QKTIINSIAK
KVDSTEIQFS EWKYYGRQLP EPKWTRKYCV CLENEQRFLI FPSYQESLNC ASAKHIPVSI
IGRQHTERPF LAVRRASCLF HEISVLTGQM VKSERSSIPC LQSLEKQHQD PSKQTVLSLH
TKLQSDDLRD ELSTALSEYK HTARSHSKSV NPNRFNRRLR AKTFAALADH VWSPFGYDET
TSLNVSVPSL AAQSTPTDIN LTGNAVSNSL SALDAAFEVS HAVLPDNPNP SVHCQLVRRT
PSRLQRFLRT LRRSFSFQHV GLDEPTQPHI PGVSQQIQAS SVRLSSDRLH TERHRRPKSN
ARLSRLFQCI TVGDVNRVNE HSGLFLLRND TSPNLEWMGN LHGNRFYSCP GGSYPNCVAL
VPLSDSLMET GTPNDSGHVT RSSTTPLFPV GDSVGSVSFI GSGHQRSVPP HGSTQLLARL
DTAPGYLLTC SGFVHFGALH PTLTGGREFC FFCSAPASTC IKSSEYQRLS SDAALLCRIF
AAPSFLSRLR WLRSLRRTAK PNLENERHRE NSLKLSILEA RNLSSKRRQV IEQMNRLPAF
LETRSNGLFL SFVYYCDICL DRTLYARTTS KTATNGIFWA EDFDLNNLPN VSVMTISLYK
EADSSNKDSR RFGTTRLGSK KYRKSQNQLV GFVTIPMSEI SGRNDVQAWL NLQPPTEPGP
RDSATVLMPV FSAHQDSLSG LAASNGLVRF GSSSVLSPTY NQQASTTQLN HLVTDQRDLP
QIRIRARYQS VDILPIRNYW ALKKFVLEHS IELTTWLEHV LPVKAKEEVA SSLIGLHECN
GTLVEFLTDL VRRDVANLEN ESMAFRSNTM ATKAVECFLK MAGSTYLHDL LYRLVQKVLA
CLTAWEVNPE KLSSSAIASG SLTIGDTATF AKTGSIGFSP PSGRPLPGSL LGNQILLLHH
LNAVWRAIQS SLPQFPSCLM RVFCSFRETL EPTHGPEFCD NLISACIFLR LICPALLSPS
LFGLVSAFPS EPSCQRNLTL LAKSLQSLAN FSAFDDKEPY MRFLNGFVSS QMSAMRTFIR
NISTWPTLTG RTDDPDTVNG FRDVIDEAFE LANLHLLLSD LPKPCNGEAS KIPGGTLPPG
ELTQLPQLLD NLSEKLRETL TPSTHSLSDL NGTQTAFQTT TERLNKTLPS RTAKSSGNRF
PTSDFSSLST SQLSTENQTT DYAFHSIPVS SPQPYYTLHQ NPGFHNPKEQ RTRPVNILSP
PAPSAPDDGR SVSQGQCVAT LFTTNDYDEP YNSPHPDSED ESYNVNGGHN GHEDYPPPPP
VPERLTNLSH ARRSSSHIDD LRALSLPMAH SVPTGLDGTR GADDEPVYDF VPSSDASSTD
DLVLTNEKYL YGSTSHQALQ TSSDRNATSL QRKSKQSSPR ELVKNRFSSR AEVNTTEEPE
SKSTEADVCT MGTALSAEHT ARSPRMVSKQ VAKAKVVLTR NNQVAPPVSL KPIAAKSPLE
TGLQSSSRQA DVPIVFSPRE DRKFSITRNG GDSYHPQNGA SRVEHRPLPN PVNPLLDETT
YDEVDGDFTG NSTKIQAETS GTPVFDACEV PMNPAVAHTD GLEHEVVRLR HQLELSRADA
ARAANRLSQQ EAELAHLRQL LSQLRAQPQL NRFPSALSNQ MSLRATVREI LSEPSCNPKT
TASEKFGLDC SAGRGIGTSF TELDDAMARL EREQAELQQE QARIRARMAA SQQTKPVSQP
KHNSYLSEAS KAHPMDVPAS SSQAGTVSSA ELRPSAQTHS YVQPTKPVRY GPRVRHDPPP
QPRKGTFSRR DVY
//
