ID A0A075AJ37_9TREM Unreviewed; 1984 AA.
AC A0A075AJ37;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=T265_12742 {ECO:0000313|EMBL:KER32704.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER32704.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER32704.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL596631; KER32704.1; -; Genomic_DNA.
DR RefSeq; XP_009163529.1; XM_009165265.1.
DR STRING; 6198.A0A075AJ37; -.
DR GeneID; 20326910; -.
DR KEGG; ovi:T265_12742; -.
DR CTD; 20326910; -.
DR OrthoDB; 2999245at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd20813; C1_ROCK; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22988:SF71; CITRON RHO-INTERACTING KINASE; 1.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 810..1093
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1094..1178
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 1784..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1950..1984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1196..1223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1259..1439
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1500..1548
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1574..1619
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1950..1968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..1984
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 839
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KER32704.1"
SQ SEQUENCE 1984 AA; 222738 MW; 2CF64974186B6D18 CRC64;
FFSFNAFQVA LKEYQAKHFV VFVRINSKKS CNSLLLNEKP STVAADIPAD EAIAVEFVVP
TGPEHNPMRR AIRRQVKVSL RSDREVWWTQ KAEELKEAQN AGNARKLFQL IRATGTRKPP
VRESLKHQNG TTISNKEERL DRWAEYFEQQ MSWPPAGTHL QPTGEVEPCT VNVEPPTASE
FYDCIFSLKR HQAPGPDDLS PGLFRDGGEV PNQYLSDLFA CIWEKESVPD NWGESVIVPI
FKKGARSECG NHRGISLTPV VTRLLASIVL RRLTVAREML TREQQAGFRP GRGCVDQIFT
LRQVLEQRHT YKRPTILVFL DFRGAFDSVD RSVLLETLAH QGMPRKFVNI IRSLYSQTSG
RRSVKEITKR FGAVGATRLP GWGPRDPHCA WLNTLQDMAA NRSSLGDGAD SDAAVFVAPL
QSGENLCPPM TSSDNLPLNE LEKQLLDPSS ECYLENLLDL VTSLVADCNY PSASNSRTVQ
AFLNRTDRVA RPASHSAAAS ARPSSVTTLN TSKSVFKPRK PVYLGTFNVR TLKQADQHVA
PARTLDSVCI DDASTVIELT APSLSSRFRL GTSWNSEAAA AGYAGGGRKT RKTRLAIEKL
VEPEVKRNYQ SQLLEYLSDG TVSDINGHWE KTSKALLKAG ASACGTTQPT SSKDWISDRT
VSLLKTRRQV PPGRHHNSTR RIIRRQKTIL VNSDLQITQL SSNLSALSAA LENVWRSDSV
RARGRNPQMY SKTTSSQLSI IAISTDDNVT NLSSYPGRRW RTISGQMTSA ISHCMKTACG
QRTAEAIVHH CPYKKASEVI EARRTKYADF EILKVIGQGG FGRVELCRHR RTRRVYAMKM
MSKQHLLDHS QSGYWEERDL MVRASSEWLV ACHHAFLDKE NVYLCMEYMP GGDLYYWLEK
YDTFNESQVR FYLAESILAL EVLHSLRFIH RDLKPDNMLL DARGHLKLAD FGSCVRVGDD
GYHYCTSPIG TPDYISPEML NCQSKPGKVG PECDWWSLGI IAFEMLFGEP AFYGQSLVET
YSRILAHEKS FKIPEDGDPP SPELENLIRA LLRSAATRLG SLAVVYENDQ SMLNDSNRAI
AASTAQVKSH PFFQNVAWHQ LRSQDPPIQP VVNSETDTSN INFDENEANS FSIGVSKLPS
TSGAFAPKKP PAPNYFTGNH LSFAGYTFNR DHIYLRGGLR GQEQVDTTPE ANRLSMSDTN
RRLQALESEV AELRATIQTL EKQAAVDQVA LKDSQRRLGE STSELDATKT HTLELEKTLS
DLRSRCATIQ AERDRLTKDI ASTKTQLQHT TEICEAERRK VSALEEEKTR LTTEIEQLHV
SLQQTQVRLQ EQLKQTEQVQ GSDDPSRQRE MISALELQVA NLQAENREAR QKATVLMTEA
SNLNRNHTKQ VAELTDQLQE AQRFCNLYQS QVTELSESCS AIESREKTLR EELNALRIQL
DTTLASKRTL TENLFSTEST LASTLVELRS AQDDLKAARE HTATEVERLQ ALANLRLAEL
NDVSGQLDEM RDRCTKAEES SFDLSEQVSR LQKERELQQR NMKAIVDKLL HEVEGRRPPG
GSKKHAKDHD HSACQQLAKN YKNLQSTSEK AKADLQRTID QQKKDLAERS EMLTRLTEES
LFKDQEISRL NALIHQLYSR LDEAPQTHST PMKGMSAAGD IGDQVSGPGS RTMIDHDSQL
DLDELYSKSL EQVVDLDSKG RGRKKLIWSP TYAVLKPFVL AFYVSRMEKE TGVGPVEEIP
LCRIIHVRKA TSADLIHAQS TDIVRTLQFF FQKEENPATS NTLLDSAESE TNTSNANLRA
AGGSGSNHHA GSDNLIRWLE HTFQPIRFRI GTVLCEVCYR PCSELRNPPP ALECTKCRMR
IHLDHVDQHQ KFASCHSAAE MRYIRLPSVA EQEKWISHMN LLVRSLRELQ QNPEKLIESG
LSAKAALAGG VTQLGTRLAI EPLYRSIRTG SAGASQQRSE LKSPTQSSMK VKVKRRESPP
KASF
//
